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PTEN Hamartoma Syndrome clinical trials

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NCT ID: NCT04094675 Active, not recruiting - Clinical trials for PTEN Hamartoma Tumor Syndrome

Sirolimus for Cowden Syndrome With Colon Polyposis

Start date: September 16, 2019
Phase: Phase 2
Study type: Interventional

Colon polyposis (the presence of multiple colon polyps) is very common with Cowden syndrome, as over 60% of patients have 50 or more polyps. In a previous clinical trial, some participants had reduction in the number of colon polyps with the use of the medication sirolimus for a very short time period. This study is investigating sirolimus and its effect on the number of colon polyps in patients with Cowden syndrome and polyposis over a 1 year period.