Clinical Trial Summary
Hypothesis
1. The supportive psychotherapy model can be structured and developed for the
non-pharmacologic therapy of acute coroner syndrome patients in intensive cardiac care
unit
2. The development of the supportive psychotherapy model can provide an improvement in
psychological function in the form of a reduction in symptoms of anxiety, depression,
and an improvement in the quality of life of acute coroner syndrome patients during
treatment at intensive cardiac care unit.
3. Psycho-patho-mechanization of supportive psychotherapy model development in the
improvement of psychosomatic function of acute coroner syndrome patients by assessing
the improvement of serotonin, cortisol, and immunoglobulin-A levels, and,
4. Development of the supportive psychotherapy model can provide improvement in somatic
function in the form of decreased complications such as arrhythmias, pericarditis,
chronic heart failure, shock and death of acute coronary syndrome patients during
treatment.
5. Psychosomatic improvements, namely anxiety, depression, and cardiac complications
associated with levels of serotonin, cortisol, immunoglobulin-A and heart rate
variability.
Research objectives 1.1 General Objectives: To develop non-pharmacologic psychotherapy as
part of holistic therapy for acute coronary syndrome patients during their treatment at
intensive cardiac care unit.
1.2 Specific Objectives:
1. Develop a structured supportive psychotherapy model
2. Proving the role of supportive psychotherapy in the improvement of psychological
symptoms of anxiety, depression and quality of life in acute coronary syndrome patients
during treatment.
3. Proving the psycho-patho-mechanism intervention of the supportive psychotherapy model in
improving psychosomatic function through the Hypothalamus-Pituitary-Adrenal pathway,
namely by assessing the improvement in levels of serotonin, cortisol, immunoglobulin-A
and heart rate variability
4. Proving the role of supportive psychotherapy in the improvement of somatic symptoms of
cardiac complications such as arrhythmias, pericarditis, chronic heart failure, shock
and death in acute coronary syndrome patients during treatment.
5. To prove the supportive psychotherapy model in psychosomatic improvement, namely
anxiety, depression, and cardiac complications associated with improvements in levels of
serotonin, cortisol, immunoglobulin-A and heart rate variability.
Introduction Acute coronary syndrome will have a high impact on who feels it.
Psycho-neuro-immunological imbalance will occur before and after the attack. To date, there
is no evidence regarding the role of supportive psychotherapy as a non-medical treatment in
acute coronary syndromes. The study will also measure cortisol, immunoglobulin-A, serotonin,
and heart rate variability for objective comparisons between intervention and usual cardiac
care.
Method This research is an operational research with a mixed method research design, namely
exploratory sequential method with qualitative method research that precedes quantitative
methods. This research is divided into two stages, namely the qualitative research stage by
developing a model of supportive psychotherapy, followed by the stage of applying the model
to clinical trials of acute coronary syndrome patients during treatment at intensive cardiac
care unit.
Result Total subject is 80 subject. All will collect blood and saliva sample, heart rate
variability. One arm will do intervention (supportive psychotherapy) and the others will do
usual cardiac care.
