Psychomotor Agitation Clinical Trial
Official title:
Quetiapine for Delirium Prophylaxis in High-risk Critically Ill Patients
Scheduled, low-dose quetiapine is effective in preventing delirium in high-risk critically ill, trauma/surgical patients. Prophylaxis also reduced ventilator duration and ICU length of stay.
Status | Completed |
Enrollment | 82 |
Est. completion date | June 2014 |
Est. primary completion date | June 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 100 Years |
Eligibility |
Inclusion Criteria: - Trauma/surgical patients admitted to the trauma/surgical ICU Exclusion Criteria: - sustained RASS of -4/-5 during the complete ICU admission - presence of a condition preventing delirium assessment - anticipated or known ICU length of stay of less than 48 hours - taking antipsychotics prior to admission - history of schizophrenia, epilepsy, parkinsonism, or levodopa treatment - primary neurologic event/injury with GCS = 9 during the first 48 hours of ICU - current treatment with a continuous infusion neuromuscular blocking agent - pregnancy - screened positive for delirium upon admission to the ICU. |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | University of Tennessee Medical Center | Knoxville | Tennessee |
Lead Sponsor | Collaborator |
---|---|
University of Tennessee Graduate School of Medicine |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Incidence of delerium | ICU length of stay | One year | No |
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