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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02612948
Other study ID # 3709
Secondary ID
Status Completed
Phase Phase 4
First received November 19, 2015
Last updated November 21, 2015
Start date November 2013
Est. completion date June 2014

Study information

Verified date November 2015
Source University of Tennessee Graduate School of Medicine
Contact n/a
Is FDA regulated No
Health authority United States: Food and Drug Administration
Study type Interventional

Clinical Trial Summary

Scheduled, low-dose quetiapine is effective in preventing delirium in high-risk critically ill, trauma/surgical patients. Prophylaxis also reduced ventilator duration and ICU length of stay.


Description:

Objective: To evaluate the efficacy of scheduled quetiapine for delirium prophylaxis in critically ill, trauma/surgical patients identified as high-risk for delirium utilizing a validated prediction model.

Design: Prospective, open-label, single-center study. Setting: Trauma/surgical intensive care unit at an academic medical center. Patients: Eighty two adult trauma/surgical patients who were admitted to the intensive care unit and were at high-risk for the development of delirium (PRE-DELIRIC Score ≥50%, past medical history of dementia, past medical history of alcohol misuse, or past medical history of drug abuse).

Interventions: Patients were randomized by unit location to receive pharmacologic prophylaxis for delirium (quetiapine 12.5 mg every 12 hours) or no pharmacologic prophylaxis for delirium within forty-eight hours of admission to the intensive care unit.

Measurements: The primary end point was the incidence of delirium during admission to the intensive care unit (ICU). Secondary end points included time to onset of delirium, ICU and hospital lengths of stay, ICU and hospital mortality, duration of mechanical ventilation, and adverse events. Delirium was assessed using the confusion assessment method for the intensive care unit.


Recruitment information / eligibility

Status Completed
Enrollment 82
Est. completion date June 2014
Est. primary completion date June 2014
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 100 Years
Eligibility Inclusion Criteria:

- Trauma/surgical patients admitted to the trauma/surgical ICU

Exclusion Criteria:

- sustained RASS of -4/-5 during the complete ICU admission

- presence of a condition preventing delirium assessment

- anticipated or known ICU length of stay of less than 48 hours

- taking antipsychotics prior to admission

- history of schizophrenia, epilepsy, parkinsonism, or levodopa treatment

- primary neurologic event/injury with GCS = 9 during the first 48 hours of ICU

- current treatment with a continuous infusion neuromuscular blocking agent

- pregnancy

- screened positive for delirium upon admission to the ICU.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


Intervention

Drug:
Quetiapine
escalating dose to prevent delerium.

Locations

Country Name City State
United States University of Tennessee Medical Center Knoxville Tennessee

Sponsors (1)

Lead Sponsor Collaborator
University of Tennessee Graduate School of Medicine

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Incidence of delerium ICU length of stay One year No
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