Ketamine and Stress in OCD — KET-OCD  

Obsessive-Compulsive Disorder Clinical Trial

Official title: Ketamine Therapy in Obsessive-compulsive Disorder and Its Effects on Neuropsychological Function Under Stress in a Cross-over Trial

Status Recruiting

Clinical Trial Summary

The main goal of this trial is to demonstrate therapeutic efficacy of low dose ketamine in patients with OCD. We expect that ketamine will alleviate symptoms in the hours following application, but also - if effective - that the anti-OCD effects might last for several days after a single infusion.

Clinical Trial Description

This study will apply a randomized, double blind, comparator-controlled cross-over design and will be conducted at the Department of Psychiatry and Psychotherapy of the Medical University of Vienna. We will include 30 participants with a primary diagnosis of OCD. Participants will undergo ketamine and comparator infusions in either inpatient- or outpatient settings to assess the therapeutic capabilities of ketamine in OCD. Furthermore, participants' neurocognitive function and stress responses will be tested with four neurocognitive tasks and a cold pressor test paradigm. Study subjects will be given an option to participate in an open-label follow up with up to 8 infusions over a period of a month. ;

Related Conditions & MeSH terms

• Mental Disorders
• Obsessive-Compulsive Disorder
• Problem Behavior
• Psychiatric Disorder

• NCT number: NCT05577585
• Study type: Interventional
• Source: Medical University of Vienna
• Contact: Christoph Kraus, MD PhD
• Phone: +4314040035680
• Email: christoph.kraus@muv.ac.at
• Status: Recruiting
• Phase: N/A
• Start date: October 1, 2022
• Completion date: June 2026