The Effect of Psoriatic Arthritis on Female Sexual Dysfunction

Psoriatic Arthritis Clinical Trial

Official title:

The Effect of Psoriatic Arthritis on Female Sexual Dysfunction and Their Relation to Sex Hormones

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06370221
• Other study ID #: psoriatic Arthritis
• Status: Not yet recruiting
• Start date: June 1, 2024
• Est. completion date: December 30, 2024

Study information

• Verified date: April 2024
• Source: Egymedicalpedia
• Contact: Eisa Hegazy, Professor
• Phone: +201094337795
• Email: eisa_mohamed4152[@]med.svu.edu.eg
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Psoriasis is one of the most common immunemediated chronic inflammatory skin disorders.

Description:

Psoriasis is one of the most common immunemediated chronic inflammatory skin disorders.

Beside genetic factors, several environmental factors such as injuries, infections, stress, drugs, and immune defect take part in autoimmune pathogenesis of the disease. In addition, it has been reported that some hormones may also have a role in the pathogenesis of psoriasis, due to their effects on keratinocytes proliferation.

Studies revealed that sex hormones manifest a variety of biological and immunological effects in the skin which modulate the natural course of psoriasis.

Approximately 20-30% of patients with psoriasis may also have psoriatic arthritis, which often causes significant musculoskeletal pain that significantly impairs quality of life (QoL).

Although sexual dysfunction is a common complaint, affecting 30 to 70% of psoriasis patients, few studies have analyzed the impact of psoriasis and psoriatic arthritis on quality of sexual life.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 180
• Est. completion date: December 30, 2024
• Est. primary completion date: December 20, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 20 Years to 40 Years

Eligibility

Inclusion Criteria:

• The study will focuses on the relationship between the FSD and PsA;

• The healthy controls will derive from a population within the same geographic area and ethnic background as PsA;

• Used the same questionnaires/instruments of FSFI to diagnose FSD

Exclusion Criteria:

• pregnancy,

• breastfeeding

• being sexually inactive

• having a partner with sexual dysfunction,

• refusing to participate, or

• being unable to read

• Females with any sexual transmitted disease

Related Conditions & MeSH terms

• Arthritis
• Arthritis, Psoriatic
• Psoriatic Arthritis

Intervention

Behavioral:
• The effect of psoriatic Arthritis
to assess the frequency rates of sexual problems and associated factors in a cohort of married females with Psoriatic arthritis, and to investigate the correlation between sex hormones profile ( estrogen and progesterone level) and female sexual function in Psoriatic arthritis patients.

Locations

Country	Name	City	State
Egypt	Qena Hospital	Qina

Sponsors (1)

Lead Sponsor	Collaborator
Egymedicalpedia

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Evaluation of female sexual function	To identify and understand the mechanisms of sexual problems in Psoriatic arthritis Patients in Qena university hospital.	6 months