Interval Training Study in Psoriatic Arthritis

Psoriatic Arthritis Clinical Trial

Official title:

Interval Training Study in Psoriatic Arthritis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02995460
• Other study ID #: 2012/1646
• Status: Completed
• Phase: N/A
• Start date: January 2013
• Est. completion date: December 2015

Study information

• Verified date: November 2018
• Source: Norwegian University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Psoriatic arthritis is a chronical inflammatory disease characterized by pain and reduced physical function. Patients have a higher risk of cardiovascular disease and a higher body mass index.

A pilot study in patients with rheumatoid arthritis has shown positive effect on inflammation after 12 weeks of high-intensity interval training.

The primary aim of this study is to determine whether high-intensity interval training affects the disease activity in psoriatic arthritis. This intervention is believed to result in benefits in terms of inflammation, body composition and risk factors for cardiovascular disease.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 67
• Est. completion date: December 2015
• Est. primary completion date: December 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• fulfilling the CASPAR criteria of psoriatic arthritis

• ability to exercise.

Exclusion Criteria:

• Inability to exercise

• very high disease Activity

• unstable ischemic cardiovascular disease

• severe pulmonary disease

• pregnancy

• breastfeeding

• drug- and alcohol addictions

Related Conditions & MeSH terms

• Arthritis
• Arthritis, Psoriatic
• Psoriatic Arthritis

Intervention

Behavioral:
• interval training
4x4 high intensity interval training

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Norwegian University of Science and Technology	Helse Midt-Norge

References & Publications (2)

Thomsen RS, Nilsen TIL, Haugeberg G, Bye A, Kavanaugh A, Hoff M. Effect of high-intensity interval training on cardiovascular disease risk factors and body composition in psoriatic arthritis: a randomised controlled trial. RMD Open. 2018 Oct 11;4(2):e0007 — View Citation

Thomsen RS, Nilsen TIL, Haugeberg G, Bye A, Kavanaugh A, Hoff M. The impact of high intensity interval training on disease activity and patient disease perception in patients with psoriatic arthritis: A randomized controlled trial. Arthritis Care Res (Hob — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Patient global assesment (PGA)	PGA is measured as a change between timepoints. PGA is registered by the patient on a visual analog scale.	Baseline, 3 months (right after intervention), 9 months
Primary	Maximal oxygen uptake (VO2 max)	The VO2 max is measured as a change between timepoints	Baseline, 3 months (right after intervention), 9 months
Secondary	Total lean mass	Total lean mass is measured as a change between timepoints and is measured by dual energy x-ray absorptiometry (DXA).	Baseline, 3 months (right after intervention), 9 months
Secondary	Total body fat	Total body fat is measured as a change between timepoints and is measured by dual energy x-ray absorptiometry (DXA).	Baseline, 3 months (right after intervention), 9 months