Psoriatic Arthritis Clinical Trial
Official title:
Distal Phalangeal Bone Involvement Observed by High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) in Patients With Nail Psoriasis
Nearly 30% of patients with cutaneous psoriasis (PsO) developed psoriatic arthritis (PsA).
Among these patients 20 % will have severe destructive arthritis. The risk of developing PsA
is significantly higher in patients with nail involvement (OR = 2.24; 95% CI [1.26-3.98]).
The risk is particularly high for the peripheral form of PsA and onycholysis (OR=2.80; 95%
CI [1.34-5.85]).
Thus the investigators wanted to test the hypothesis that onycholysis, in patients without
PsA, is a potential clinical marker of subclinical distal enthesopathy and, by extension, of
bone micro-structural alterations.
Patients and Methods
The investigators will recruit 4 groups of subjects:
1. Patients with peripheral PsA,
2. Patients with psoriatic nail onycholysis,
3. Patients with PsO only
4. Healthy match control subjects. The investigators will assess the presence of
enthesopathy by ultrasonography and bone structural damages (by HR-pQCT) in all
subjects at baseline and 4 years.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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