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Clinical Trial Summary

This study examines the effect of IL-23 blockade with Guselkumab on the immune cells of scalp psoriasis lesions.


Clinical Trial Description

This is a one-arm, open-label study to examine the effect of Guselkumab . Guselkumab is a FDA-approved medication for the treatment of psoriasis. This study will examine how Guselkumab affects immune cells within scalp psoriasis lesions. Ten subjects with moderate to severe scalp psoriasis will be enrolled. Biopsy samples will be collected and undergo molecular profiling to correlate profiles with Guselkumab treatment response. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05858632
Study type Interventional
Source University of California, San Francisco
Contact Jeffrey Cheng, MD, PhD
Phone 415 575 0524
Email rashes@ucsf.edu
Status Recruiting
Phase Phase 4
Start date July 1, 2023
Completion date June 30, 2026

See also
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Recruiting NCT04099979 - A Pilot Study to Explore the Role of Gut Flora in Psoriasis
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Recruiting NCT05938361 - Efficacy of Tildrakizumab in Difficult-to-treat Areas in Psoriasis
Completed NCT00216879 - Efficacy and Safety of Calcipotriol Plus Betamethasone Dipropionate Gel for up to a Year in Scalp Psoriasis Phase 3
Completed NCT00216840 - Efficacy and Safety of Calcipotriol Plus Betamethasone Dipropionate Gel in Scalp Psoriasis Phase 3