Clinical Trials Logo
  1. Home
  2. Pseudoxanthoma Elasticum
  3. NCT05025722

Pseudoxanthoma Elasticum (PXE) Natural History Biomarkers in PXE Individuals and Their Biological Non-PXE Siblings

Pseudoxanthoma Elasticum Clinical Trial

Official title:
An Evaluation of Pseudoxanthoma Elasticum (PXE) Natural History Biomarkers in PXE Individuals and Their Biological Non-PXE Siblings

Clinical Trial Summary

This PXE biomarker study aims to characterize the levels of inorganic pyrophosphate (PPi), pyridoxal 5´-phosphate (PLP), and other biomarkers relevant to PXE and ectopic calcification in both PXE patients and their biological siblings who are PXE carriers or normal non-PXE individuals.

Clinical Trial Description

This non-interventional PXE study is designed to assess differences in circulation levels of selective biomarkers related to PXE and tissue-nonspecific alkaline phosphatase (TNAP) inhibition, between PXE patients, PXE carriers, and non-PXE normal individuals. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05025722
Study type Observational
Source Daiichi Sankyo, Inc.
Contact
Status Completed
Phase
Start date August 30, 2021
Completion date August 11, 2022
View Details
See also
  Status Clinical Trial Phase
Completed NCT02537054 - Intravitreal Aflibercept for Therapy of Patients With Pseudoxanthoma Elasticum (PXE) Phase 2
Completed NCT05569252 - A Study of DS-1211b in Individuals With PseudoXanthoma Elasticum Phase 2
Recruiting NCT05662085 - Progression Rate of Pseudoxanthoma Elasticum-associated Choroidal and Retinal Degeneration
Completed NCT03070860 - What's Happen Under the Calcification Process in Pseudoxanthoma Elasticum N/A
Completed NCT01446393 - Functional and Structural Characterization of Arteriopathy in Pseudoxanthoma Elasticum (PXE) N/A
Completed NCT00470977 - Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy Phase 1/Phase 2
Recruiting NCT03758534 - Natural History of GACI With or Without ARHR2 or PXE
Recruiting NCT05734196 - The ENERGY Study: Evaluation of Safety and Tolerability of INZ-701 in Infants With ENPP1 Deficiency or ABCC6 Deficiency Phase 1
Not yet recruiting NCT06462547 - ADAPT Study: Long-term Safety Study of INZ-701 in Patients With ENPP1 Deficiency and ABCC6 Deficiency Phase 2
Recruiting NCT01446380 - Phenotypic Expressions in a French Pseudoxanthoma-Elasticum Cohort N/A
Recruiting NCT03813550 - Intestinal Microbiota and Vitamin K Levels in PXE Patients (IMPROVE Study) N/A
Not yet recruiting NCT03364504 - Biological Collection of Kidney Cells N/A
Active, not recruiting NCT02108392 - Characterization of Pseudoxanthoma Elasticum
Recruiting NCT01731080 - Arterial Wall Calcium Load in Pseudoxanthoma Elasticum N/A
Completed NCT00555113 - Evolution of Visual Impairment During Pseudoxanthoma Elasticum N/A
Completed NCT00341419 - Genetic Analysis of Patients With Pseudoxanthoma Elasticum
Withdrawn NCT04441671 - Oral Pyrophosphate Absorption in PXE Disease Phase 2
Recruiting NCT04868578 - PPI Supplementation to Fight ECtopIc Calcification in PXE N/A
Completed NCT01525875 - Magnesium Supplements In The Treatment Of Pseudoxanthoma Elasticum (PXE) Phase 2
Completed NCT05246189 - Employment of Patients With Pseudoxanthoma Elasticum