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Pseudoarthrosis of Bone clinical trials

View clinical trials related to Pseudoarthrosis of Bone.

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NCT ID: NCT06103396 Enrolling by invitation - Pseudarthrosis Clinical Trials

Treatment of Nonunion Fractures With Mesenchymal Stromal Cells (MSCs)

MSC
Start date: January 30, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The goal of this study is to evaluate the bone regeneration capacity of BM-MSC (Bone marrow mesenchymal stromal cells), in patients with nonunion. BM-MSC cultured are seeded on a collagen scaffold, included into autologous platelet-rich plasma (PRP) clot, and implanted in the nonunion bone defect.

NCT ID: NCT05423561 Completed - Clinical trials for Pseudoarthrosis of Bone

Corticalisation After Femoral Nail Dynamization in Hypertrophic Non-unions

Start date: January 1, 2010
Phase: N/A
Study type: Interventional

In 12 patients with corticalization and hypertrophic pseudarthrosis were present after dynamization, the old nail was removed and nail exchange was performed with a longer and larger diameter nail to pass the region formed in the cortex approximately 2-3cm inferior from the old nail.

NCT ID: NCT05183542 Recruiting - Clinical trials for Pseudoarthrosis of Bone

SPECT/CT Bone Scan Quantification Surgery

PERQUAL
Start date: April 29, 2022
Phase: N/A
Study type: Interventional

The hypothesis of our study is that SPECT/CT bone scan fixation quantified by SUVMAX on a CZT solid state camera preoperatively would identify good responders to lumbar arthrodesis surgery.

NCT ID: NCT05049915 Recruiting - Clinical trials for Pseudoarthrosis of Bone

Evaluation of the Clinical Effectiveness of Bioactive Glass (S53P4) in the Treatment of Tibia and Femur Non-unions

Start date: June 1, 2018
Phase: N/A
Study type: Interventional

Abstract Background: Treatment of non-union remains challenging and often necessitates augmentation of the resulting defect with an autologous bone graft (ABG). ABG is limited in quantity and its harvesting incurs an additional surgical intervention leaving the risk for associated complications and morbidities. Therefore, artificial bone graft substitutes that might replace autologous bone are needed. S53P4-type bioactive glass (BaG) is a promising material which might be used as bone graft substitute due to its osteostimulative, conductive and antimicrobial properties. In this study, the investigators plan to examine the clinical effectiveness of BaG as a bone graft substitute in Masquelet therapy in comparison with present standard Masquelet therapy using an ABG with tricalciumphosphate to fill the bone defect. Methods/design: This randomized controlled, clinical non-inferiority trial will be carried out at the Department of Orthopedics and Traumatology at Heidelberg University. Patients who suffer from tibial or femoral non-unions with a segmental bone defect of 2-5 cm and who are receiving Masquelet treatment will be included in the study. The resulting bone defect will either be filled with autologous bone and tricalciumphosphate (control group, N = 25) or BaG (S53P4) (study group, N = 25). Subsequent to operative therapy, all patients will receive the same standardized follow-up procedures. The primary endpoint of the study is union achieved 1year after surgery. Discussion: The results from the current study will help evaluate the clinical effectiveness of this promising biomaterial in non-union therapy. In addition, this randomized trial will help to identify potential benefits and limitations regarding the use of BaG in Masquelet therapy. Data from the study will increase the knowledge about BaG as a bone graft substitute as well as identify patients possibly benefiting from Masquelet therapy using BaG and those who are more likely to fail, thereby improving the quality of non-union treatment.

NCT ID: NCT03620305 Completed - Clinical trials for Pseudoarthrosis of Bone

Septic Pseudarthrosis Of Long Bone : Experience In A Regional Reference Center

Start date: April 1, 2018
Phase:
Study type: Observational

Description of septic pseudarthrosis with chirurgical treatment in two steps (first step : Implementation of cement, second step : bone reconstruction, with or without device)