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Pseudarthrosis clinical trials

View clinical trials related to Pseudarthrosis.

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NCT ID: NCT01756144 Not yet recruiting - Pseudarthrosis Clinical Trials

rhBMP-2 vs Autologous Bone Grafting for the Treatment of Non-union of the Docking Site in Tibial Bone Transport

Start date: July 2015
Phase: N/A
Study type: Interventional

When there is a bone defect, bone transport is used to bridge the defect. Frequently, the bone in the docking site (where the transported bone comes together) doesn't heal. The objective is to study the effectivity of rhBmp-2 (inductos) to stimulate bone healing, in order to find new techniques to treat non-union of long bones. The method of the study is a randomized controlled trial, to compare rhBMP-2 and autologous bone grafting in stimulating bone healing in the docking site.

NCT ID: NCT01528072 Terminated - Clinical trials for Degenerative Spondylolisthesis

Dynesys Spinal System Post Market 522 Study

Start date: March 2012
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the safety and fusion rates following posterior lateral fusion with the Dynesys Spinal System used as an adjunct to fusion and compare to literature control.

NCT ID: NCT01461005 Terminated - Spondylolisthesis Clinical Trials

A Postmarket Surveillance Study of the Paradigm Spine Dynamic Stabilization System (DSS)

DSS
Start date: September 2011
Phase: N/A
Study type: Interventional

The purpose of the Post-Market Surveillance study is to evaluate safety.

NCT ID: NCT01409954 Enrolling by invitation - Clinical trials for Pseudarthrosis After Fusion or Arthrodesis

Collecting Bone Graft During Spinal Decompression and Posterolateral Lumbar Fusion to Better Define Bone Making Cells

Start date: October 2011
Phase:
Study type: Observational

The purpose of this study is to improve fusion (bony healing) techniques and improve patient recovery by identifying cells in your body that make bone. Patients with spine problems often need surgeries that include fusion (bony healing) of vertebrae (bones in your back) together in order to hold the bones steady allowing them to heal together (fusion). If the vertebrae (back bones) fail to heal together, which occurs about 10-15% of the time, it can result in a slower recovery and may require revision (another) surgery. By using a small portion of the graft taken during surgery the investigators hope to define the cells that make bone most efficiently. This will help reduce the need for revision surgeries and improve patient recovery.

NCT ID: NCT01362413 Completed - Clinical trials for Nonunion of Fracture [Pseudarthrosis], Site Unspecified

Validation of Laboratory Test for Predicting Bone Tissue Regeneration

Rebone-test
Start date: January 2011
Phase: N/A
Study type: Observational

The aim of the study is to determine whether the evaluation of pro-osteogenic activity of autologous serum may predict the effectiveness of platelet gel in regenerating bone tissue in patients with nonunions of long bones. Serum samples will be collected before the surgery, and their pro-osteogenic activity will be evaluated by using a bioactivity test (mineralization assay). In order to determine whether the pro-osteogenic activity of the serum is able to discriminate between individuals who will achieve or will not achieve bone consolidation, the laboratory results will be correlated with clinical and radiographic results at 12 months, when patients will be considered as healed or not healed.

NCT ID: NCT01246934 Completed - Clinical trials for TIBIA PSEUDOARTHROSES

Segment Transport Versus Acute Shortening In The Treatment of Tibial Pseudarthroses With Bone Loss

Start date: October 2009
Phase: N/A
Study type: Interventional

In this study the investigators are presenting the advantages as well as the disadvantages of ACUTE SHORTENING AND RELENGTHENINIG VS SEGMENT TRANSPORT methods.

NCT ID: NCT00916981 Completed - Pseudarthrosis Clinical Trials

Treatment of Atrophic Nonunion by Preosteoblast Cells

Start date: November 2008
Phase: Phase 1/Phase 2
Study type: Interventional

Treatment of nonunion, delayed union and malunion fractures of long bones remains problematic. The definition of nonunion is a failure of the fracture to heal in six months in a patient in whom progressive repair had not been observed radiographically between the third and sixth month after the fracture. First of all good surgical techniques are stable immobilization must be obtained and local sepsis excluded. Then stimulation of the callus is required. Numerous techniques have been developed ranging from invasive interventions (including internal fixation with the use of bone graft or bone graft substitutes) to non invasive procedures (ultrasound and pulsed electromagnetic fields). Recently, autologous cell therapy was presented as an interesting approach. The concept of such therapies is based on the effect of stem cells presented in the bone marrow and able to be transformed in osteoblast cells. The percutaneous technique of autologous bone-marrow grafting is a minimally invasive alternative able to produce a good healing of the fracture. The efficacy is dependent of the concentration in progenitor cell reinjected. An optimization of this type of treatment could be achieved using a technique to increase the differentiation of the bone marrow cells in preosteoblasts before the injection in situ by an adequate culture. Therefore we would like to start a pilot open study on the feasibility and the efficacy of implantation of preosteoblasts into nonunion. Two different presentations exist: the atrophic and the hypertrophic pseudarthrosis in relationship with radiological features of bone proliferation at the tip of bone fragments. Some data support that atrophic and hypertrophic nonunion fractures could have different physiopathological factors. So, in a first time we only would evaluate the atrophic form and to determine in an open study the effect of the implantation of preosteoblasts into atrophic nonunion.

NCT ID: NCT00726128 Completed - Trauma Clinical Trials

Patient Outcomes Evaluation of the EBI Vuelock™ Anterior Cervical Plate System

VueLock
Start date: August 1998
Phase:
Study type: Observational

To prospectively collect radiographic and outcome data on patients who are having cervical spine fusion surgery with the VueLock™ Anterior Cervical Plate System

NCT ID: NCT00557635 Suspended - Clinical trials for Tibia or Femur Pseudo-arthrosis

Osseous Setting Improvement With Co-implantation of Osseous Matrix and Mesenchymal Progenitors Cells From Autologous Bone Marrow

Start date: January 2008
Phase: Phase 2
Study type: Interventional

Sometime osseous reconstruction needs allogeneic bone, in this study we use Ostéopure™ from Ostéobanque d'Auvergne, which is a osseous matrix. However Ostéopure™ integration lasts a long time. To optimize this integration we purpose to associate mesenchymal progenitors cells from autologous bone marrow.

NCT ID: NCT00424567 Terminated - Pseudarthrosis Clinical Trials

Feasibility Study of Aastrom Tissue Repair Cells to Treat Non-Union Fractures.

Start date: October 2003
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this multi-center study is to obtain clinical data to substantiate that Aastrom TRC autologous bone marrow cells will regenerate bone in patients with established (appendicular skeletal) non union fractures, when used with one of the commonly employed commercially available allograft chip matrices.