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Clinical Trial Summary

Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics. However, these injections can be quite painful, which leads many patients to discontinue treatment. Often, the injection involves a mixture of local anesthetic and corticosteroids despite a lack of evidence that the use of lidocaine improves pain. Due to the acidic pH, the lidocaine component of the injection can actually cause a significant burning sensation during the procedure. Lidocaine does not have anti-inflammatory properties and does not treat the underlying pathology. By including another medication, lidocaine also adds cost and risk to the procedure. The purpose of this study is to see if removing lidocaine from intralesional injections decreases the pain of injection.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • Acne
  • Alopecia
  • Alopecia Areata
  • Cicatrix, Hypertrophic
  • Epidermal Cyst
  • Epidermal Inclusion Cyst
  • Frontal Fibrosing Alopecia
  • Granuloma
  • Granuloma Annulare
  • Hypertrophic Scar
  • Keloid
  • Keratoacanthoma
  • Lichen Plano-Pilaris
  • Lichen Planus
  • Lichen Simplex Chronicus
  • Morphea
  • Neurodermatitis
  • Nummular Eczema
  • Plaque Psoriasis
  • Prurigo
  • Prurigo Nodularis

NCT number NCT03630198
Study type Interventional
Source Vanderbilt University Medical Center
Contact
Status Completed
Phase Phase 4
Start date October 1, 2018
Completion date September 1, 2019

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