Proteinuria Clinical Trial
Official title:
Effect of Oral Supplementation With Curcumin (Turmeric) in Patients With Proteinuric Chronic Kidney Disease
The purpose of this study is to determine if the oral supplementation with curcumin reduces proteinuria in patients with chronic kidney disease regardless the ethiology.
Curcumin is a potent antioxidant found in extracts of the rhizome of the plant Curcuma longa
L.
Different studies have demonstrated that curcumin has potent biological activity and
therefore is an effective therapeutic agent for the treatment of various ailments.
This compound acts as a bifunctional antioxidant:
ه is capable of reacting directly with highly reactive oxygen species. ه acts indirectly by
its ability to induce the expression of various cytoprotective proteins through
Keap1/Nrf2/ARE pathway.
Although RAAS blockade is the cornerstone to prevent the progression of proteinuric
nephropathy, a significant number of patients remained with proteinuria and progress to
end-stage renal disease.
Due to the low cost and few side effects of curcumin, this could become an adjuvant
treatment of proteinuric nephropathy purposes attenuate the progression of chronic kidney
disease.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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