Proteinuria Clinical Trial
Official title:
The Effects of Weight Reduction in Chronic Proteinuric IgA Nephropathy
The study aims to explore the non-pharmacological treatment of IgA nephropathy by weight reduction. The investigators hypothesized that benefits of weight loss may reduce proteinuria.
This is a prospective randomized study in adult IgA nephropathy. The investigators enrolled 30 patients who have proteinuria exceeds 1 g per day with biopsy proven IgA nephropathy. The experimental arm recieves the non-pharmacological treatment, weight reduction protocol. All patients in this arm must be reduce their body weight in 3-5 % from baseline as protocol. Another arm is control group which recieves standard treatment of IgA nephropathy including ACEIs/ARBs for blood pressure control (target < 130/80 mmHg). The primary outcome is proteinuria level. The secondary outcome is cytokines and inflammatory markers level including interleukin-6, resistin, adiponectin, leptin and monocyte chemoattractant protein-1. ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03510286 -
Validation of a PrCr Dipstick Diagnostic Test in Ghana
|
||
| Completed |
NCT05086549 -
An Observation Study to Evaluate the Renoprotective Effect of Fimasartan in Patients With DKD and Proteinuria
|
||
| Terminated |
NCT04051957 -
Isosorbide Mononitrate For Anti-Vascular Endothelial Growth Factor (VEGF) Induced Kidney Injury
|
Phase 2 | |
| Completed |
NCT02232763 -
Efficacy and Safety of Losartan in Pediatric Chronic Kidney Disease With Tubular Proteinuria
|
Phase 3 | |
| Terminated |
NCT02057523 -
Acthar as Rescue Therapy for Transplant Glomerulopathy in Kidney Transplant Recipients
|
Phase 4 | |
| Completed |
NCT02226055 -
An Investigation Into the Cardiovascular Risk and Aetiology of CKDu in Sri Lanka
|
N/A | |
| Completed |
NCT00493727 -
Use of Mucomyst to Ameliorate Oxidant Stress in Diabetics With Proteinuria
|
N/A | |
| Active, not recruiting |
NCT00565396 -
Effectiveness Study on Fosinopril and/or Losartan in Patients With Chronic Kidney Disease Stage 3
|
N/A | |
| Recruiting |
NCT05759754 -
Effects of Traditional Chinese Medicine (GSJYF) in Children With Inherited Proteinuric Kidney Disease
|
N/A | |
| Withdrawn |
NCT02882373 -
Arginine in Treating Patients With Anti-VEGF Induced Kidney Injury
|
Phase 2 | |
| Completed |
NCT02327403 -
Belatacept Conversion in Proteinuric Kidney Transplant Recipients
|
Phase 2 | |
| Completed |
NCT00915200 -
N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
|
Phase 2 | |
| Completed |
NCT01029002 -
The Effects of Vitamin D Repletion in Vitamin D Deficient Patients With Stage 3 and 4 Chronic Kidney Disease
|
Phase 3 | |
| Withdrawn |
NCT00541619 -
Sympathetic Overactivity in Essential Hypertension
|
N/A | |
| Withdrawn |
NCT00392132 -
Impact of Screening Patients With HIV for Kidney Disease
|
||
| Terminated |
NCT00001978 -
Determination of Kidney Function
|
||
| Recruiting |
NCT05457283 -
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
|
Phase 3 | |
| Completed |
NCT04874753 -
The Effect of COVID-19 Pandemia on Follow up of Patients With Chronic Kidney Disease
|
||
| Recruiting |
NCT02972346 -
Availability Study of ACTH to Treat Children SRNS/SDNS
|
N/A | |
| Unknown status |
NCT02256995 -
uChek Pilot Study for Urinalysis in the Antenatal Care Setting
|
N/A |