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Supplementation Trial on Arginine With Metabolic Profiling — STAMP  

Protein Clinical Trial

Official title:
Supplementation Trial on Arginine With Metabolic Profiling

Clinical Trial Summary

This study will assess effects of an acute dose of the amino acid arginine on metabolism in healthy young men.

Clinical Trial Description

A double - blind randomized, crossover design trial examining arginine vs. placebo beverage treatments will be performed. The primary objective is to determine the effects of arginine assessed by standard laboratory assays and metabolomics. To accomplish the objective standardized meals will be provided for 2 days preceding treatment for dietary consistency. Participants will arrive at the center following a 10-12 hr fast. Blood samples will be collected at baseline (fasting), 1.5 hrs, 3.0 hrs, 6.0 hrs, and 24 hrs post treatment. Plasma prolactin, growth hormone, amino acids, glucose, insulin, triacylglycerols, thyroid hormones (TSH, T3, and T4), sex hormone binding globulin (SHBH), testosterone, cortisol, DHEA, and citrulline will be measured. Metabolomics will be measured at 3 time points for each treatment. Peripheral arterial tonometry (PAT) will also be performed at ~2 hrs following treatment to examine endothelial function in response to nitrous oxide release. In addition, psychological status including fatigue will be assessed using a standardized mood questionnaire (POMS). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03409380
Study type Interventional
Source Pennington Biomedical Research Center
Contact
Status Completed
Phase N/A
Start date February 8, 2018
Completion date July 8, 2019
View Details
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