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Optimal Protein Dose Per Meal During Weight Loss in Perspective to Maintaining Muscle Mass

Protein Metabolism Clinical Trial

Official title:
Optimizing Per Meal Protein Intake During Weight Loss

Clinical Trial Summary

The primary aim of the trial is to determine the optimal dose of protein per meal in relation to enhancing muscle protein synthesis and thereby in perspective counteract muscle loss during weight loss. In addition, we aim to determine whether the response to protein intake is reduced in women on hypocaloric diet compared to in women on an energy-balanced diet.

Clinical Trial Description

Aim of this project is to determine the optimal protein dose (high quality milk protein) per meal in relation to enhancing muscle protein synthesis and thereby counteract muscle loss during weight loss.

The hypothesis is that the optimum dose of protein for women on a hypocaloric diet will be greater than when women eat an energy sufficient diet, and also higher than the optimal dose previously determined in weight stable men.

Methods: Forty women (~ 50 years) will be randomized to four groups. Following a five day hypocaloric diet (three groups) or an energy balanced diet (one group). The women will report to the laboratory to ingest one of three different protein doses. The muscle protein response to the different doses of protein will be determined by the muscle protein fractional synthetic rates using tracer kinetics. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03326284
Study type Interventional
Source University of Aarhus
Contact
Status Completed
Phase N/A
Start date August 1, 2017
Completion date February 1, 2018
View Details
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