Clinical Trials Logo

Clinical Trial Summary

The investigators will examine the effects of a given amount of a protein food source such as pork, mixed nuts, and tofu on anabolic response at the whole body and muscle levels in young, healthy adults.


Clinical Trial Description

Over the past 35 years the United States Department of Agriculture (USDA) Dietary Guidelines for Americans (DGAs) has sought to translate recommendations on nutrient requirements (i.e., Recommended Dietary Allowances) from the Food and Nutrition Board of the Institute of Medicine (IOM) into practical nutritional advice for the American public. Although the DGAs are intended to incorporate additional scientific evidence, the lack of appropriate focus on protein nutrition is a major shortcoming of the DGAs. Not only is the amount of protein not a major focus, absolutely no mention is made of protein quality. In general, animal proteins have much higher the Digestible Indispensable Amino Acid Scores (DIAASs) than plant proteins, often by as much as two fold. Account has not been taken of DIAAS, or even the general concept of the importance of the amount and profile of essential amino acids in individual proteins, in formulation of MyPlate or the scientific report of the DGAs Committee. This is because a classification does not apply to most plant proteins, despite the fact that in the IOM report stating the Recommended Dietary Allowance for protein it is specified that this refers to "high quality protein. To help the consumer meet protein needs while achieving the goal of varied protein food sources, the DGAs Committee published "ounce equivalents" in the protein foods group. It is stated among other equivalents cited, that 1 ounce (oz.) of meat is equivalent to 1 tablespoon (Tbsp.) of peanut butter and 1/4 cup (0.5 ounces) of cooked kidney beans. But are they really equivalent? This indicates that the "ounce equivalents" of protein foods in MyPlate are not equivalent in any parameter that might be used to assess nutritional benefit, and demonstrates that the bias against animal proteins is in the Dietary Guidelines. The misrepresentation of the equivalencies of various food sources of protein in MyPlate raises the question of the process by which this occurred, and how can the process be influenced to more accurately reflect that high quality of animal proteins? Therefore, developing convincing data to correct the MyPlate "ounce equivalents" of protein foods is an achievable goal. In general, dietary protein intake serves many physiological roles, but the most prominent is the maintenance or gain of body protein. This is accomplished by stimulation of protein synthesis, the inhibition of protein breakdown, or a combination. Thus, the functional response to consumption of a given amount of a protein food source is best assessed by quantifying the rates of protein synthesis and breakdown at the whole body level as well as at the muscle level in order to calculate the anabolic response. The investigators propose to make these measurements in response to intake of "equivalent "(according to MyPlate) amounts of pork, mixed nuts and tofu. Moreover, the functional responses to these varied sources of protein we will examine coincide with the predictions from the USDA nutrient data base, and calculation of the DIAAS will provide needed support to redefine "ounce equivalents" of protein food sources according to those data bases for all animal and plant sources of protein. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03179462
Study type Interventional
Source University of Arkansas
Contact
Status Completed
Phase N/A
Start date December 1, 2017
Completion date July 1, 2019

See also
  Status Clinical Trial Phase
Completed NCT01143493 - The Role of Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease
Active, not recruiting NCT01461603 - Local Effects of Amino Acids and 3-hydroxybutyrate in the Bilaterally Perfused Human Leg N/A
Completed NCT04422665 - Preventing Bed-rest Induced Muscle Loss in the Elderly N/A
Completed NCT04121689 - Time Course of Postprandial Protein Metabolism N/A
Completed NCT01820702 - Short Term Bed Rest Study: Evaluation of the Use of Artificial Gravity, Induced by Short-arm Centrifugation N/A
Completed NCT03142737 - Are the "Ounce-equivalents" in the Protein Foods Groups Really Equivalent? N/A
Completed NCT03952884 - Skeletal Muscle Protein Synthetic Response to Amino Acid and Peptides N/A
Completed NCT05197140 - Role of the Protein Matrix in the Anabolic Response to a Ground Beef Patty as Opposed to the Impossible (Vegi-) Burger N/A
Completed NCT04821557 - Effect of Microbial Protease Supplementation on Postprandial Amino Acid Levels N/A
Recruiting NCT05400733 - Prandial Metabolic Phenotype in Adults N/A
Terminated NCT00586807 - Metabolic Response to Infliximab in Pediatric Ulcerative Colitis N/A
Completed NCT01276795 - Whey Protein-based Enteral Nutrition Support to Improve Protein Economy in Surgical Patients N/A
Completed NCT00586352 - Protein Metabolism in Newly Diagnosed Pediatric Inflammatory Bowel Disease N/A
Completed NCT03037294 - Protein Turnover in the Osteoarthritic Knee N/A
Completed NCT01509456 - The Effect of Potassium Bicarbonate on Bone and Several Physiological Systems During Immobilisation N/A
Completed NCT00583232 - Protein and Energy Metabolism in Pediatric Crohn's Disease Phase 1
Completed NCT03326284 - Optimal Protein Dose Per Meal During Weight Loss in Perspective to Maintaining Muscle Mass N/A
Completed NCT03147001 - Protein Ingestion Before Training Low N/A
Active, not recruiting NCT00497380 - Arginine Feeding: a Novel Strategy to Improve Protein Metabolism in Cancer and the Response to Surgery N/A