Protein Ingestion Before Training Low

Protein Metabolism Clinical Trial

Official title:

Nutritional Strategies for Optimizing Adaptations and Recovery Following Training 'Low'.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03147001
• Other study ID #: 50968
• Status: Completed
• Phase: N/A
• First received: May 8, 2017
• Last updated: May 8, 2017
• Start date: April 30, 2016
• Est. completion date: January 10, 2017

Study information

• Verified date: May 2017
• Source: University of Aarhus
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A randomized interventions study using a crossover design. Ten well trained triathletes or bikeriders will be included for to undergo two trail separated by about 3 weeks. The night before the trail each subject will performe a high intense interval trainings session on an ergometer bike. during the night an infusion of aminoacid tracers will be initiated. The subject is woken at 6.30 a.m. Blood samples and a musclebiopsy will be collected prior to the morning bike ride at 8.00a.m. Immediately before the morning bike ride is started the subject will ingest a drink of 0,5g protein or a non-caloric placebo (random order). During the bike ride and the following 4,5 hours blood will be drawn with regular intervals. at time point 0, 60 and 180 min after the training session biopsies are collected.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 9
• Est. completion date: January 10, 2017
• Est. primary completion date: January 10, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Healthy well-trained triathletes or cyclists

• VO2max > 55 ml O2/kg/min

• Training and has been training more than 7 times a week the last 6 months.

Exclusion Criteria:

• VO2max < 55 ml O2/kg/min

• Has chronic disease

• has incjected with tracer on a previous occasion.

Related Conditions & MeSH terms

• Protein Metabolism

Intervention

Other:
• Protein ingestion
A protein drink was ingested prior to the 90min bike ride in one of the completed trails (order randomised).
• Non-caloric placebo ingestion
A placebo drink was ingested prior to the 90min bike ride in one of the completed trails (order randomised).

Locations

Country	Name	City	State
n/a

Sponsors (4)

Lead Sponsor	Collaborator
University of Aarhus	Arla Foods, Innovation Fund Denmark, Team Denmark

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle protein fractional synthetic rate (FSR)		FSR was measure over at time period of six hours
Secondary	Tracer kinetics dilution model	A-V tracer dilution model was applied across the forearm.	six hours
Secondary	Muscle signalling	Muscle signalling will be determined using western blotting in each muscle biopsy	Determined in biopsies sampled before and immediatly after 90min exercise in addition to one and four hours after exercise.
Secondary	Nitrogen excretion	nitrogen excretion is determined by Plasma and urinary carbide analysis as well as plasma NH4+.	Urine is collected during two periods. Collection period one: 12 hours prior to morning exercise. Collection period 2: During and four hours following exercise. Blood samples is drawn repeatedly from before to four hours after exercise.