Critical Illness Clinical Trial
Official title:
Local Effects of Amino Acids and 3-hydroxybutyrate in the Bilaterally Perfused Human Leg
Introduction: Protein loss during critical illness is an important problem and is shown to
predict overall survival. In animal studies, infusion of leucine is shown to increase the
synthesis of muscle protein by 30-40% and decrease protein degradation by 30%.
Objectives: Compared to saline, an amino acid or 3hydroxybutyrate infusion in the femoral
artery will promote protein synthesis and inhibit breakdown assessed with local a/v
phenylalanine and tyrosine tracer kinetics in healthy volunteers. These effects will include
distinct alterations in muscle signal events, in particular mTOR.
Methods: n = 10 healthy male subjects are equipped with catheters in aa. femorals and vv.
femorals bilaterally under local anaesthetics. Each study comprises a 3-hour basal period
and a 3-hour period with hyperinsulinaemic-euglycaemic clamp. During the test, samples of
arterial and venous blood and 4 muscle biopsies are obtained. The intervention contain
continues saline infusion compared to either amino acids (Vamin) or 3hydroxybutyrate
solution FFa-3OHB.
Perspectives: This study elucidates the direct effect of aminoacids and ketone bodies on
muscle protein metabolism in humans and contribute to further development of nutritional
therapy in human catabolic states.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment
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