Ulcerative Colitis Clinical Trial
Official title:
Metabolic Response to Infliximab in Pediatric Ulcerative Colitis
The metabolic response to ulcerative colitis, including increased proteolysis and lipolysis
and changes in energy expenditure, plays a significant role in the resulting malnutrition
from which these patients suffer. Tumor necrosis factor-alpha (TNF-alpha), a
pro-inflammatory cytokine, has been found to be elevated in children with ulcerative
colitis. TNF-alpha has been incriminated in the mechanism of weight loss in many different
chronic diseases, and causes net protein and lipid catabolism. Anti-TNF-alpha antibody
(infliximab) has been proven to be an effective therapy for ulcerative colitis.
The purpose of this study is to determine changes in protein and lipid metabolism, as well
as resting energy expenditure, before and after therapy with anti-TNF-alpha antibody
(infliximab) in children with ulcerative colitis. Performing this study will better define
the changes in nutrition status observed in these children following remission of active
ulcerative colitis, and potentially lead to changes in medical and nutritional management of
these children
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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