Protein Digestion Kinetics Clinical Trial
Official title:
Health Effects of Sustainable Future Proteins
In the current study the investigators aim to assess the nutritional quality and bio-functional activity of two alternative protein sources bovine plasma and corn and from the benchmark protein whey. The study is a double blind, randomised, cross-over, short-term trial in which 36 healthy study subjects will receive three protein interventions of 1 week with a washout period of 1 week between interventions. Study subjects will visit the research facility before and after the intervention period on two separate occasions to measure gut permeability via a multi-sugar test and to collect fasting blood samples and blood pressure outcomes. Faecal and saliva samples before and after each intervention will be collected. A subgroup of 12 study participants will also be subjected to a postprandial digestibility test on the first day of the interventions. The main study parameter is to assess the protein digestion kinetics and protection of the epithelial barrier. Secondary study parameters include other markers of gastrointestinal health, metabolic health, vascular health and satiating properties.
In the current study the investigators aim to assess the nutritional quality and
bio-functional activity of two alternative protein sources bovine plasma and corn and from
the benchmark protein whey. The objective is to assess the degree of digestibility and
protection of the epithelial barrier of two alternative protein concentrates from corn and
bovine plasma and of the commonly consumed benchmark protein whey. These outcomes will also
be used to evaluate how predictive the in vitro-measurements have been for the obtained in
vivo-effects. Secondary objectives are to assess the impact on other markers of
gastrointestinal health, metabolic health, vascular health and satiating properties. Study
design: The study is a double blind, randomised, cross-over, short-term trial in which 36
study subject will participate. Study subjects will receive three protein interventions of 1
week with a washout period of 1 week between interventions. Study subjects will visit the
research facility before and after the intervention period on two separate occasions to
measure gut permeability via a multi-sugar/acetylsalicylic acid test and to collect fasting
blood samples and blood pressure outcomes. Faecal and saliva samples before and after each
intervention will be collected. All measurements will be conducted after an overnight fast
and a standardised evening meal prior to the study days. A subgroup of 12 study participants
will also be subjected to a postprandial digestibility test on the first day of the
interventions.
Study population: healthy study subjects, between 35-70y, BMI 18 - 30kg/m2, both males and
females.
Intervention (if applicable): Three intervention arms of one week; a bovine plasma protein
intervention, a corn protein intervention and a whey protein comparator intervention. Study
subjects will receive 40 grams of protein per day during the intervention in two 20 g doses.
Main study parameters/endpoints: The main study parameter is to assess the protein digestion
kinetics and protection of the epithelial barrier. Secondary study parameters include other
markers of gastrointestinal health, metabolic health, vascular health and satiating
properties.
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