Ghrelin Levels in Patients With Protein C Deficiency

Protein C Deficiency Clinical Trial

Official title:

Investigation of Ghrelin Levels in Patients With Protein C Deficiency

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04180657
• Other study ID #: 69965
• Status: Not yet recruiting
• Start date: January 2020
• Est. completion date: July 2020

Study information

• Verified date: October 2019
• Source: University of Aarhus
• Contact: Sascha S Horup, MD
• Phone: +45 27149089
• Email: SASHOR[@]rm.dk
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

In rodents with protein C deficiency elevated levels of ghrelin has been observed. The purpose of this study is to investigate if patients with protein C deficiency also have elevated levels of ghrelin, and if so, how this affects the patients.

30 patients with protein C deficiency and 30 healthy BMI and gender matched controls are recruited. Bloodsamples are taken in order to measure ghrelin and GH levels and other metabolic parameters. The patients and controls are also asked to answer a questionaire regarding appetite.

If patients with protein C deficiency have higher levels of ghrelin than the general population, this will lead to new studies that will perhaps help us understand the importance of ghrelin in humans.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 60
• Est. completion date: July 2020
• Est. primary completion date: April 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• protein C deficiency or healthy subjects

• age 18-70

• BMI 18-35

• written statement to join the study

Exclusion Criteria:

• chronic illness, apart from protein C deficiency and lifestyle diseases

• everyday medication apart from statins, oral diabetes medication and antihypertensive drugs.

• blood donation within three months prior to the investigation.

• Alcohol abuse

Related Conditions & MeSH terms

• Protein C Deficiency

Intervention

Genetic:
• Protein C deficiency
The effect of protein C deficiency on ghrelin levels are investigated.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Aarhus

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	acyl ghrelin and des acyl ghrelin measured in mg/dl		6 month
Secondary	Growth hormone measured in pmol/L		6 month