Protamine Adverse Reaction Clinical Trial
Official title:
Investigation of Anaphylactic Reaction in Cases Undergoing Cardiac By-Pass Surgery
The investigators aim to assess tryptase test efficacy for measuring the allergic response to protamine during cardiac bypass surgery. Additionally, the investigators aim to establish a differential diagnosis on the basis of potential allergens or clinical causes.
Venous blood samples from cardiac surgery cases will be obtained for tryptase measurement upon admission to the operating room (OR) and immediately prior to and 30 min after protamine infusion initiation. A rapid effect-response-based clinical assessment will be made using clinical and laboratory monitoring data for diagnosis and treatment decisions during protamine infusion, which may complicate the recovery from surgery. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03583567 -
Effect of Anti-histamine in Prevention Systolic Hypotension After Protamine
|
Phase 4 | |
| Not yet recruiting |
NCT06254404 -
Impact of Protamine Dose Reduction on Platelet Aggregation After Extracorporeal Circulation for Minimally Invasive Aortic Valve Replacement Surgery
|
N/A |