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Bacteriophage Therapy in Patients With Prosthetic Joint Infections (PJI) — ACTIVE2  

Prosthetic Joint Infection Clinical Trial

Official title:
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of APT Phage Bank Phage Therapy Versus Placebo in Conjunction With Debridement, Antibiotics, and Implant Retention (DAIR) in Subjects With Chronic Prosthetic Joint Infection (PJI)

Clinical Trial Summary

This is a study designed to evaluate bacteriophage therapy in patients with chronic prosthetic joint infections.

Clinical Trial Description

This is a study designed to evaluate bacteriophage therapy in patients with chronic prosthetic joint infections of the hip or knee caused by at least 1 of the following organisms: Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus lugdunensis, Streptococcus spp., Enterococcus faecium, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, or Klebsiella pneumoniae. This study will compare the safety and efficacy of DAIR procedure + Phage Therapy + Antibiotics versus DAIR procedure + Placebo + Antibiotics. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05269134
Study type Interventional
Source Adaptive Phage Therapeutics, Inc.
Contact
Status Withdrawn
Phase Phase 2
Start date March 27, 2023
Completion date July 2027
View Details
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