Prostatic Carcinoma Clinical Trial
Official title:
Detection of Malignant Calcifications in High Grade Prostate Cancer With Comedo-type Necrosis Using Thin Section Computed Tomography and Susceptibility Weighted Magnetic Resonance Imaging
Management of prostatic carcinoma varies according to stage of disease. Trans-rectal
ultrasound guided biopsy is known to underestimate the degree of tumor due to undersampling
and random non-targeted technique. Methods to improve pre-operative tumor localization and
grading, including multi-parametric (MP) magnetic resonance imaging (MRI) is an active area
of research but requires further validation.
High grade tumors can undergo comedo-type necrosis with malignant calcifications which only
occurs in Gleason pattern 5 tumors and which we hypothesize can be reliably detected using
computed tomography (CT) and/or MRI.
Detection of malignant calcification within tumor foci will improve the accuracy of
localization and grading in prostatic carcinoma.
High grade (Gleason pattern 5) tumors can undergo comedo-type necrosis producing malignant calcifications which we hypothesize can be reliably detected using computed tomography (CT) and/or MRI. Detection of malignant calcifications in areas of Gleason pattern 5 tumor will improve the accuracy of pre-operative localization and grading in prostatic carcinoma. ;
Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Diagnostic
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05428319 -
Expression of STEAP-1 and p40 in Prostatic Carcinoma and Its Mimickers
|