Prostate Neoplasms Clinical Trial
— NTTProOfficial title:
Combining Multi-omics Analysis and Organoid Models to Search for Novel Therapy Target in Metastatic Prostate Cancer
Verified date | October 2022 |
Source | Fudan University |
Contact | Yao Zhu |
Phone | +86 15001818005 |
mailzhuyao[@]163.com | |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The aim of this study is to use multiomics sequencing to explore the molecular characteristics of metastatic prostate cancer (mPCa), especially metastatic castration-resistant prostate cancer (mCRPC). At the same time, mCRPC models will be constructed, including organoids and animal models, serving as a basic and translational research platform to help identify novel drug targets for mPCa.
Status | Not yet recruiting |
Enrollment | 100 |
Est. completion date | May 1, 2026 |
Est. primary completion date | November 1, 2025 |
Accepts healthy volunteers | No |
Gender | Male |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: 1. Histologically confirmed prostate cancer 2. metastatic disease confirmed by image examination 3. Patients who can undergo surgery or biopsy for prostate cancer 4. Able to provide informed consent Exclusion Criteria: 1. Patients diagnosed with other types of cancer besides prostate cancer 2. Not accessible to surgery sample 3. Patients fail to provide informed consent 4. Other situation that researchers think are unsuitable for this study |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Fudan University |
Akhoundova D, Rubin MA. Clinical application of advanced multi-omics tumor profiling: Shaping precision oncology of the future. Cancer Cell. 2022 Sep 12;40(9):920-938. doi: 10.1016/j.ccell.2022.08.011. Epub 2022 Sep 1. Review. — View Citation
Gao D, Vela I, Sboner A, Iaquinta PJ, Karthaus WR, Gopalan A, Dowling C, Wanjala JN, Undvall EA, Arora VK, Wongvipat J, Kossai M, Ramazanoglu S, Barboza LP, Di W, Cao Z, Zhang QF, Sirota I, Ran L, MacDonald TY, Beltran H, Mosquera JM, Touijer KA, Scardino PT, Laudone VP, Curtis KR, Rathkopf DE, Morris MJ, Danila DC, Slovin SF, Solomon SB, Eastham JA, Chi P, Carver B, Rubin MA, Scher HI, Clevers H, Sawyers CL, Chen Y. Organoid cultures derived from patients with advanced prostate cancer. Cell. 2014 Sep 25;159(1):176-187. doi: 10.1016/j.cell.2014.08.016. Epub 2014 Sep 4. — View Citation
Guo C, Figueiredo I, Gurel B, Neeb A, Seed G, Crespo M, Carreira S, Rekowski J, Buroni L, Welti J, Bogdan D, Gallagher L, Sharp A, Fenor de la Maza MD, Rescigno P, Westaby D, Chandran K, Riisnaes R, Ferreira A, Miranda S, Calì B, Alimonti A, Bressan S, Nguyen AHT, Shen MM, Hawley JE, Obradovic A, Drake CG, Bertan C, Baker C, Tunariu N, Yuan W, de Bono JS. B7-H3 as a Therapeutic Target in Advanced Prostate Cancer. Eur Urol. 2022 Sep 13. pii: S0302-2838(22)02633-1. doi: 10.1016/j.eururo.2022.09.004. [Epub ahead of print] — View Citation
Wei Y, Wu J, Gu W, Qin X, Dai B, Lin G, Gan H, Freedland SJ, Zhu Y, Ye D. Germline DNA Repair Gene Mutation Landscape in Chinese Prostate Cancer Patients. Eur Urol. 2019 Sep;76(3):280-283. doi: 10.1016/j.eururo.2019.06.004. Epub 2019 Jun 24. Review. — View Citation
Yerly L, Pich-Bavastro C, Di Domizio J, Wyss T, Tissot-Renaud S, Cangkrama M, Gilliet M, Werner S, Kuonen F. Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma. Nat Commun. 2022 Aug 20;13(1):4897. doi: 10.1038/s41467-022-32670-w. — View Citation
Zhu Y, Mo M, Wei Y, Wu J, Pan J, Freedland SJ, Zheng Y, Ye D. Epidemiology and genomics of prostate cancer in Asian men. Nat Rev Urol. 2021 May;18(5):282-301. doi: 10.1038/s41585-021-00442-8. Epub 2021 Mar 10. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Multiple omics features | Multi-omics information including genetic profiling results, transcriptional profiling results and epigenomic profiling results will be collected and analyzed. | 3 years | |
Primary | Organoids successfully generated from metastatic prostate cancer | Successful isolation of prostate cancer organoids from surgical specimens of patients diagnosed with metastatic prostate cancer. We will calculate the culture efficiency and total number of organoids generated in our center. | 3 years | |
Primary | Developing of biomarkers related to cancer metastasis and drug resistant | To search for biomarkers related to tumor metastasis and resistance by performing multi-omics analysis to surgery specimens derived from patients with metastatic prostate cancer. | 3 years | |
Secondary | Animal models successfully generated from patient derived prostate cancer organoids | Prostate cancer organoids with clarified characteristics will be transplanted into mice to establish PDOX models. | 3 years | |
Secondary | Response of the prostate cancer organoids to the selected anti-cancer compounds | Organoid that are successfully cultured and characteristic clarified will be treated with the selected compounds to test their anti-cancer activity. | 3 years | |
Secondary | Response of the PDOX models to the selected anti-cancer compounds | PDOX models that successfully established will be treated with the selected compounds to test their anti-cancer activity. | 3 years |
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