Prostate Cancer Screening Clinical Trial
— ProCaSSOfficial title:
Evaluation of An Online Intervention In Improving General Practitioners' Practice In Prostate Cancer Screening
Verified date | April 2019 |
Source | University of Malaya |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The incidence of prostate cancer has been rising steadily both globally and in Malaysia.
Besides an ageing population, another reason cited to explain the increase, is the
corresponding increase in the prostate cancer screening rates, especially using non-invasive
tests like the prostate specific antigen (PSA).
General practitioners, being front liners in medicine, play an important role in helping men
make an informed decision on prostate cancer screening. In Malaysia, about 50% of GPs would
routinely screen asymptomatic men and 95% of them would use PSA as a screening tool. Despite
this, the evidence for screening is inconclusive, as evidenced from two major trials on
screening [The European Randomised Study of Screening for Prostate Cancer (ERSPC) and
Prostate, Lung, Colorectal and Ovarian Cancer Screening trial (PLCO)]. Furthermore, clinical
practice guidelines globally provide conflicting recommendations on this subject, and none
has been published in Malaysia to date.
Therefore, our study aims to determine the effectiveness of an online training module in
helping GPs' better understand the controversies surrounding prostate cancer screening, and
in so doing, improve their practice of screening. The investigators hypothesise that GPs who
are randomised to receive their online module will be less inclined to screen unnecessarily
for prostate cancer.
Status | Active, not recruiting |
Enrollment | 96 |
Est. completion date | June 25, 2019 |
Est. primary completion date | April 15, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Full time general practitioners in the Klang valley (Petaling district and Kuala Lumpur) Exclusion Criteria: - GPs who do not see male patients |
Country | Name | City | State |
---|---|---|---|
Malaysia | Department of Primary Care Medicine, University of Malaya Medical Centre | Kuala Lumpur | Lembah Pantai |
Lead Sponsor | Collaborator |
---|---|
University of Malaya |
Malaysia,
Andriole GL, Crawford ED, Grubb RL 3rd, Buys SS, Chia D, Church TR, Fouad MN, Gelmann EP, Kvale PA, Reding DJ, Weissfeld JL, Yokochi LA, O'Brien B, Clapp JD, Rathmell JM, Riley TL, Hayes RB, Kramer BS, Izmirlian G, Miller AB, Pinsky PF, Prorok PC, Gohagan JK, Berg CD; PLCO Project Team. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med. 2009 Mar 26;360(13):1310-9. doi: 10.1056/NEJMoa0810696. Epub 2009 Mar 18. Erratum in: N Engl J Med. 2009 Apr 23;360(17):1797. — View Citation
Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, Kwiatkowski M, Lujan M, Lilja H, Zappa M, Denis LJ, Recker F, Páez A, Määttänen L, Bangma CH, Aus G, Carlsson S, Villers A, Rebillard X, van der Kwast T, Kujala PM, Blijenberg BG, Stenman UH, Huber A, Taari K, Hakama M, Moss SM, de Koning HJ, Auvinen A; ERSPC Investigators. Prostate-cancer mortality at 11 years of follow-up. N Engl J Med. 2012 Mar 15;366(11):981-90. doi: 10.1056/NEJMoa1113135. Erratum in: N Engl J Med. 2012 May 31;366(22):2137. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Evaluation of effectiveness of online training module among general practitioners in prostate cancer screening | Difference in the change in proportions of appropriate prostate cancer screening from baseline by GPs between intervention (online training module) and control (no online training module) groups. | Through study completion, an average of 6 months | |
Secondary | Post-online training module knowledge in prostate cancer screening | Difference in the post-online training module knowledge and attitudes towards prostate cancer screening between the intervention and control groups. GPs' characteristics that are associated with prostate cancer screening |
An average of 6 months |
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