Prostate Adenocarcinoma Clinical Trial
Official title:
Molecular PET/MR Imaging in Vivo Validation of Biomarker for Human Prostate Cancer
Primary objective:
To correlate the blood/urine metabolomic biomarkers with PET/MR imaging.
Secondary objectives:
1. To evaluate the sensitivity and specificity of the PET/MR in diagnosis of prostate
cancer.
2. To examine the diagnostic performance among subgroups of defined high-risk and low-risk
subjects.
3. To interrogate the metabolomic alterations with the molecular PET/MR to develop workable
panel biomarkers.
According to 2015 National Comprehensive Cancer Network (NCCN) guideline, medical imaging
plays important roles for detection and staging for PCa, in addition to blood or urine
biomarkers. Although there are a number of very different diagnostic imaging methods, e.g.
transrectal ultrasound (TRUS), computed tomography (CT), magnetic resonance (MR) imaging and
spectroscopy, or 18F-FDG positron emission tomography (PET), none of these have gained a
dominant role as the optimum method for all clinical scenarios.The recently added
armamentarium, PET/MR, might improve diagnosis in this regard.
Therefore, we conduct this trial to identify the ability of [11C]Choline PET/MR to evaluate
the patients with prostate cancer, especially under the circumstance of elevated PSA level.
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