Periodontitis Clinical Trial
Official title:
Longterm Outcome After Dental Implant Treatment
The general aim of this project is to investigate the long-term treatment outcome after implant therapy. The patients' satisfaction with implant treatment will be studied and correlated to biological and technical problems. The survival rates of implants at patient level and the degree of bone loss of remaining teeth and implants will be calculated. The levels of cytokines and bone loss markers in peri-implantitis sites and periodontal defects and at healthy sites will be analyzed in order to study the correlation between cytokine and bone loss marker levels, and clinical conditions. Independent variables which could be regarded as significant risk factors or risk predictors on the incidence of peri-implantitis are aimed to be identified
- A questionnaire study will investigate patient satisfaction 8-14 years after dental
implant therapy to study if complications influence the degree of satisfaction/quality
of life. The questionnaire will be sent to 587 patients treated at The Specialist Clinic
Skanstull.
- A clinical examination of a minimum 150 patients who answered the questionnaire will be
performed:
- to study the incidence of biological and technical complications on dental implants
after a minimum of 10 year of function.
- to study the survival rates of implants at patient level and the degree of bone loss of
remaining teeth and implants. In addition, the correlation between bone loss of
remaining teeth and bone loss of implants will be studied.
- samples taken from the gingival crevicular fluid to investigate the profile of cytokines
and bone resorption markers as well as to study the intra-individual correlation of
cytokines and bone markers in gingival crevicular fluid from sites with peri-implantitis
and periodontal defects in individuals with dental implants.
- in addition, the salivary cytokine and bone resorption markers will be analyzed in order
to identify disease-specific biomarkers as well as to study the correlation between the
cytokine/bone resorption markers in saliva and in gingival/peri-implant crevicular
fluid.
- To identify significant risk factors or risk predictors on the incidence of
peri-implantitis.
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