PONV Clinical Trial
Official title:
Comparison of Ramosetron Pre-treatment Time for Postoperative Nausea and Vomiting (PONV) and QTc Prolongation
Ramosetron is commonly used to prevent postoperative nausea and vomiting (PONV) in the Eastern Asia. The prolongation of QTc interval is a main side effect. In this study, the pre-treatment time of ramosetron to decrease PONV, and QTc prolongation is compared.
This prospective study evaluate 42 female patients who underwent laparoscopic gynecologic
surgery under general anesthesia. Group I (n=21) receive 0.6mg of ramosetron at anesthesia
induction. Group R (n=21) received the same at the end of surgery. PONV is evaluated at
arrival to post-anesthetic care unit (PACU), before induction, discharge from PACU, 24-, 48-,
and 72- after discharge from PACU. The QTc interval is checked before anesthesia, at arrival
to PACU, and 24-h after discharge from PACU.
Forty two subjects are needed with an α value of 0.05, a power of 0.8, and effect size
difference of 0.9.
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