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Prolapse clinical trials

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NCT ID: NCT02680145 Completed - Clinical trials for Pelvic Organ Prolapse

Prediction of Postsurgical Symptomatic Outcomes With Preoperative Pessary Use

Start date: March 11, 2016
Phase: N/A
Study type: Interventional

This is a single center, prospective trial of pessary use prior to reconstructive pelvic floor surgery for pelvic organ prolapse. The goal of the study is to evaluate the change in pelvic floor symptoms with pessary use and subsequent reconstructive surgery. Additionally, we will assess the impact that preoperative pessary use has on patient self-reported preparedness for surgery.

NCT ID: NCT02667002 Completed - Clinical trials for Pelvic Organ Prolapse

Comparison of Anatomic Results Between Bilateral and Conventional Abdominal Sacral Hysteropexy

Start date: November 2015
Phase: N/A
Study type: Interventional

Investigators separated 20 patients with uterovaginal prolapse into 2 groups according to random numbers table. In one group, conventional abdominal sacral hysteropexy will be perform and another group bilateral abdominal sacral hysteropexy will be perform with polypropylene mesh. After 1 mont operation vaginal configuration will be evaluate with MRI on three plane (axial, sagittal, coronal). Then the results of thus two groups will be compare to results of nullipara patients. Investigators will investigate which technique keep the vaginal axis is closer to the original anatomic position.

NCT ID: NCT02665585 Completed - Clinical trials for Cerebrovascular Disease

Plaque Prolapse Prevention Carotid Artery Stenting (3PCAS)

3PCAS
Start date: November 2014
Phase: N/A
Study type: Interventional

The aim of the present positive-control study is to analyze and compare the rate of off-table subclinical neurological events in two groups of patients submitted to carotid artery stenting (CAS) with two different kind of stents, a close-cell stent, and the new mesh-covered stent, so to verify if the new model of stent is effective in preventing postprocedural carotid plaque embolism.

NCT ID: NCT02642835 Completed - Clinical trials for Pelvic Organ Prolapse

A Long Term Follow up of Anterior Meshes for Recurrent Prolapse

Start date: August 2015
Phase:
Study type: Observational

Prolapse of the vaginal wall and uterus are common conditions affecting up to 50% of parous women. The socioeconomic, psychological and physical impacts of prolapse are considerable. 11% of women will undergo a surgical repair by the age of 80 years. The commonest compartment affected is the anterior vaginal wall. Unfortunately there is a significant rate of recurrent prolapse or a failure of the primary procedure. This has lead to the introduction of new techniques and the use of different materials to augment the repair. Mesh augmented repairs aim to reduce the rate of recurrent prolapse. However, the use of synthetic mesh is associated with complications which are not found in non mesh repairs. 10% of women will have a mesh complication of which 70% will require a further surgical procedure to manage the complication. There are extra costs associated with purchasing the mesh, with longer operating times to insert the mesh and managing complications caused by the mesh. Balancing the extra risks of mesh surgery against the benefits is probably one of the most contentious issues in urogynaecology at the present time. Regulatory authorities in the USA (FDA) and UK (MHRA) have become increasingly interested in the use of mesh to support the vaginal wall in prolapse surgery due to risks and complications being reported. To date there is little evidence regarding the long term safety and efficacy of anterior mesh repairs. This study aims to rectify this deficiency for Perigee.

NCT ID: NCT02609555 Completed - Rectal Prolapse Clinical Trials

TEM Assisted Perineal Rectopexy in Treatment of Rectal Prolapse

Start date: October 2014
Phase: N/A
Study type: Interventional

Curvilinear incision in the postanal space, through the intersphincteric plane, insertion of Proctoscope of TEM technique and dissection till sacral promontory, insertion of mesh between the rectum and sacrum, post anal repair then anal cerclage width absorbable suture.

NCT ID: NCT02605135 Completed - Clinical trials for Stress Urinary Incontinence

Host Response to Pessaries in Microbial Communities of the Postmenopausal Vagina

Start date: April 2016
Phase:
Study type: Observational

The ability to determine the postmenopausal vaginal environment and the impact of pessary use could help to maximize pessary therapy and non-surgical treatment for such a prevalent problem.

NCT ID: NCT02601326 Completed - Clinical trials for Complete Rectal Prolapse

Laparoscopic Ventral Mesh Rectopexy Versus Delorme's Operation in Management of Complete Rectal Prolapse

Start date: January 2012
Phase: N/A
Study type: Interventional

A comparative randomized study between laparoscopic ventral mesh Rectopexy and Delorme's procedure in treatment of complete rectal prolapse to ass both efficacy and complications

NCT ID: NCT02585544 Completed - Genital Prolapse Clinical Trials

Ambulatory Prolapse Surgery

PROLAMBU
Start date: October 15, 2015
Phase: N/A
Study type: Interventional

Day surgery is performed in the same way as in full hospital admission, allowing same-day discharge without increased risk. It provides many grounds for patient satisfaction. Progress in surgical and anesthesia techniques now allows this form of management to be developed and prioritized. Day-care surgery for prolapse has been little studied. The present study is intended to help extend its future implementation, the primary objective being to assess the feasibility of the day-care approach in prolapse surgery. The secondary objectives are to study criteria of non-eligibility for day-care prolapse surgery, reasons for patients' refusal, causes of failure, predictive factors for failure, patient satisfaction, postoperative complications, 2-year anatomic and functional results, pain, quality of life and sexuality, and postoperative onset of dyspareunia and urinary incontinence. The design is for a prospective non-randomized study conducted in 3 gynecologic surgery sites managed by the Lyon hospitals board (Hospices Civils de Lyon).

NCT ID: NCT02548858 Completed - Clinical trials for Pelvic Organ Prolapse

Perineorrhaphy Outcomes Related to Body Imagery

POETRY
Start date: August 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether performing a perineorrhaphy during a reconstructive surgery indicated for pelvic organ prolapse (POP) affects a patient's body image.

NCT ID: NCT02512341 Completed - Clinical trials for Mitral Valve Prolapse

Automatic Differentiation of Innocent and Pathologic Murmurs in Pediatrics

Start date: November 2013
Phase:
Study type: Observational [Patient Registry]

The purpose of this preliminary clinical study is to assess the quality of a computational algorithm that automatically classifies murmurs of phonocardiograms (PCGs) as either pathologic (AHA class I) or as no- or innocent (AHA class III) in the pediatric population. Each patient is auscultated and diagnosed independently by a medical specialist by means of a standard mechanical stethoscope. Additionally, for each patient, a PCG is recorded using a Littmann 3200 electronic stethoscope and later analyzed using the computational algorithm. An echocardiogram is performed as the gold-standard for determining heart pathologies. The results of the computer aided auscultation (CAA) are compared to the findings of the medical professionals as well as to the echocardiogram findings. Hypothesis: The specific CAA algorithms used in this study are able to differentiate pathologic (AHA class I) from no- or innocent murmurs (AHA class III) in a pediatric population.