Effects of Coenzyme Q10 in PSP and CBD

Progressive Supranuclear Palsy Clinical Trial

Official title:

Effects of Coenzyme Q10 in PSP and CBD, A Randomized, Placebo-Controlled, Double Blind Cross Over Pilot Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00532571
• Other study ID #: CoQ10 with PSP/CBD
• Status: Completed
• Phase: Phase 2/Phase 3
• Start date: January 2004
• Est. completion date: September 2005

Study information

• Verified date: June 2018
• Source: Lahey Clinic
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To compare the efficacy, safety and tolerability of Coenzyme Q 10 versus placebo in patients with atypical parkinsonian syndromes corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) ).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Est. completion date: September 2005
• Accepts healthy volunteers: No
• Gender: All
• Age group: 40 Years and older

Eligibility

Inclusion Criteria:

• Patients fulfilling the diagnostic criteria of PSP and CBD (above) and who were diagnosed within the past 5 years

• Age > 40

• Subjects receiving anticholinergics, amantadine, dopamine agonists, carbidopa/levodopa, eldepryl, or comtan must be on a stable dose for at least 30 days prior to baseline visit.

• Patients agreeable to participate in the study.

Exclusion Criteria:

• Prior or concurrent therapy with anticholinergics, amantadine,a dopamine agonist,carbidopa/levodopa or comtan within 30 days of the baseline visit.

• Parkinsons disease or any other atypical parkinsonism; Parkinsonism due to drugs.

• History of pallidotomy, thalamotomy, deep brain stimulation or fetal tissue transplant.

• Previous use of coenzyme Q10 within 60 days of the baseline visit.

Related Conditions & MeSH terms

• Nervous System Diseases
• Neurological Disorders
• Progressive Supranuclear Palsy
• Supranuclear Palsy, Progressive

Intervention

Drug:
• CoQ10

Locations

Country	Name	City	State
United States	Lahey Clinic	Burlington	Massachusetts

Sponsors (1)

Lead Sponsor	Collaborator
Lahey Clinic

Country where clinical trial is conducted

United States,