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Effect of Simvastatin on the Prognosis of Primary Primary Sclerosing Cholangitis (PSC) — PiSCATIN  

Primary Sclerosing Cholangitis Clinical Trial

Official title:
Effect of Simvastatin on the Prognosis of Primary Sclerosing Cholangitis (PSC); A Randomized, Double-blind, Placebo Controlled Multicenter Study

Clinical Trial Summary

This is a randomized, double-blind, placebo controlled multicenter study. A total of 700 patients will be included. The study will include patients with primary sclerosing cholangitis (PSC) for daily intake of 40 mg simvastatin/placebo for 5 years. The aim is to study effect of prognosis of PSC by long term intake of simvastatin. Outcome measures are death, liver transplantation, cholangiocarcinoma or bleeding from esophageal varices. Subjects will be randomized (1:1) between Simvastatin and placebo.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04133792
Study type Interventional
Source Karolinska University Hospital
Contact Annika Bergquist, MD PhD
Phone 0707214907
Email annika.bergquist@ki.se
Status Recruiting
Phase Phase 3
Start date October 1, 2020
Completion date May 15, 2027
View Details
See also
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