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Primary Sclerosing Cholangitis With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Effects — PSC  

Primary Sclerosing Cholangitis Clinical Trial

Official title:
Treatment of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease Patients With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Effects

Clinical Trial Summary

Determine the benefit of oral vancomycin therapy for Primary Sclerosing Cholangitis.

Clinical Trial Description

The purpose of this study is to evaluate changes in the fecal and salivary/urinary microbiota during vancomycin treatment of children and adults with Primary Sclerosing Cholangitis (PSC), identify features of the host microbiota that are associated with disease activity and/or response to treatment and further delineate the immunological effects of oral vancomycin treatment of PSC. This study will correlate changes in microbiota with the immunological effects of oral vancomycin in children and adults with PSC. The results of this proposal will lead to new and validated targets for diagnosis and treatment of PSC that will have high impact in the short and long term for patients and their families.

Interim results were published in Abarbanel et al, J Clin Immunol 2013 (see References). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01802073
Study type Interventional
Source Stanford University
Contact
Status Completed
Phase Phase 3
Start date January 2012
Completion date August 2015
View Details
See also
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