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Primary Orthostatic Tremor clinical trials

View clinical trials related to Primary Orthostatic Tremor.

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NCT ID: NCT02978924 Completed - Clinical trials for Primary Orthostatic Tremor

Trans-spinal Direct Current Stimulation in Primary Orthostatic Tremor

STOP
Start date: January 17, 2017
Phase: N/A
Study type: Interventional

To explore the effect of cathodal tsDCS vs sham tsDCS in primary orthostatic tremor. The investigators hypothesize that cathodal tsDCS but not sham tsDCS would be able to restore both motor and sensory pathways of the spinal cord leading to functional improvements.

NCT ID: NCT02441985 Completed - Clinical trials for Primary Orthostatic Tremor

rTMS Therapy for Primary Orthostatic Tremor

Start date: August 2015
Phase: N/A
Study type: Interventional

Primary orthostatic tremor(POT) is a rare progressive functionally disabling tremor disorder. The characteristic features of POT are symptoms of unsteadiness in legs reported by patients when they are standing and improvement of symptoms upon walking and sitting. Due to the limited success of other treatment options there is a clear merit in continuing efforts to explore and investigate novel treatment modalities. Transcranial magnetic stimulation (TMS) is a well-established physiological tool to understand brain function. When repetitious TMS pulses are delivered to a specific target at predefined stimulation parameters, it is referred to as rTMS therapy.The investigators propose a novel approach to investigate the clinical and physiological effects of low frequency rTMS therapy in POT. The overarching hypothesis of this study is that low frequency rTMS therapy delivered to the cerebellum will modulate the cerebellar excitability and result in clinical improvements.In order to determine the physiological effects related to rTMS, the tremor physiology will also be recorded with surface electromyography (EMG). The investigator will also record the changes in cerebellum excitability in response to rTMS using cerebello-cortical inhibition (CBI), a well-established TMS parameter.