Clinical Trials Logo
  1. Home
  2. Primary Immune Deficiency
  3. NCT05476653

A Prospective Monocentric Study to Assess the Concordance of Lung MRI Compared to Chest CT Scan to Assess the Extent and Severity of Bronchial and Parenchymal Pulmonary Lesions in Adult Patients With Primary Immune Deficiency (PID) . — IRMvsSCANNER  

Primary Immune Deficiency Clinical Trial

Official title:
A Prospective Monocentric Study to Assess the Concordance of Lung MRI Compared to Chest CT Scan to Assess the Extent and Severity of Bronchial and Parenchymal Pulmonary Lesions in Adult Patients With Primary Immune Deficiency (PID): IRM vs SCANNER

Clinical Trial Summary

Currently, there is no official recommendations for the respiratory surveillance of patients with PID.However, it is recommended to perform a chest CT scan each 5 years or before any significant therapeutic change. The methods of surveillance need to meet two contradictory imperatives: - monitor frequently enough not to diagnose with delay an aggravation of bronchiectasis or interstitial pneumonitis, an infectious complication by a slowly growing pathogen such as a non-tuberculous mycobacterium, or lymphoid proliferation. - do not expose these often young patients to significant irradiation by a considerable number of scans during their life. In addition, some patients with PID have increased radiosensitivity without a safe irradiation threshold having been determined. To make thoses requirements effective, the solution is to combine radiological monitoring and absence of irradiation. Therefore, it makes sense to study whether chest scans can be replaced by MRI, non-irradiating imaging. But the question that needs to be answered is whether the information provided by the chest MRI is not inferior to that provided by the scanner. The objective of this study is to assess the ability of MRI performed with ultrashort echo time to analyze the extent and severity of bronchial and pulmonary parenchymal lesions during the follow-up of patients with primary immunodeficiency, comparing them to those of the chest CT scan.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05476653
Study type Interventional
Source Hopital Foch
Contact Elisabeth Hulier-Ammar,PHD
Phone 0146251175
Email drci-promotion@hopital-foch.com
Status Recruiting
Phase N/A
Start date November 3, 2021
Completion date May 2023
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05321407 - COVID-19 Vaccine Responses in PIDD Subjects
Completed NCT01199705 - Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (Japan Study) Phase 3
Recruiting NCT05070455 - An Open Label, Multicenter Study to Evaluate the Pharmacokinetics, Efficacy and Safety of ASCENIV™ (IGIV) in Pediatric Subjects With Primary Immunodeficiency Diseases (PIDD) Phase 4
Recruiting NCT03836690 - Transfer of Effector Memory T Cells (Tem) Following Allogeneic Stem Cell Transplantation Phase 1
Completed NCT01461018 - Multicenter Study of Long-Term Clinical Outcomes of Subcutaneous Immune Globulin IgPro20 in Subjects With Primary Immunodeficiency (Japan Study) Phase 3
Completed NCT04581460 - Primitive Immunodeficiency and Pregnancy
Completed NCT00419341 - Study of Subcutaneous Immunoglobulin in Patients With PID Requiring IgG Replacement Therapy Phase 3
Active, not recruiting NCT02868333 - Determinants of Health Status and Quality of Life in Patients With Primary Immunodeficiencies Inhereted Diagnosed During Childhood N/A
Completed NCT01166074 - Retrospective Chart Review of Subcutaneous IgG Use in Infants N/A
Recruiting NCT05932316 - Evaluating Bronchodilator Response in Patients With Bronchiectasis N/A
Recruiting NCT04784364 - Biologics And Clinical Immunology Cohort at Sinai
Completed NCT06014463 - Evaluation of Adult Patients With Immunodeficiency Within the Scope of the ICF
Recruiting NCT04459689 - COVID-19 in PID Survey
Completed NCT02711228 - Study of Immune Deficiency Patients Treated With Subcutaneous Immunoglobulin (IgPro20, Hizentra®) on Weekly and Biweekly Schedules Phase 4
Recruiting NCT04919018 - Characterizing the Upper Airway Manifestations in Primary Ciliary Dyskinesia and Primary Immunodeficiencies
Completed NCT00719680 - Extension Study of Subcutaneous Immunoglobulin Human in Patients With Primary Immunodeficiency (PID) Phase 3
Terminated NCT00023504 - Antibody Production in Immune Disorders Phase 4
Recruiting NCT00246857 - Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell Death
Recruiting NCT04565015 - Study of Immune Globulin Intravenous (Human) GC5107 in Pediatric Subjects With Primary Humoral Immunodeficiency Phase 3
Recruiting NCT04702243 - Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults