Vitamin D Deficiency Clinical Trial
Official title:
Randomized Controlled Trial of Vitamin D Repletion Regimens in Primary Hyperparathyroidism
This study will look at the effect of 2 treatment regimens that contain vitamin D in a six-month treatment trial of patients with PHPT who are vitamin D deficient. Patients will be assigned randomly to one of 2 regimens, and will be followed with tests of their blood, urine and bones. This study should provide important information on the effect of vitamin D therapy in patients with PHPT. In addition, data from this study will guide physicians as to how best to treat their patients who have PHPT and vitamin D deficiency.
Primary hyperparathyroidism (PHPT) is a common disease in which the parathyroid glands
produce excessive amounts of parathyroid hormone (PTH), which regulates calcium levels. In
primary hyperparathyroidism, high levels of PTH remove too much calcium from bones and
deposit the excess calcium in the blood, which is then filtered into the urine by the
kidneys. Bone health is threatened by the excess calcium loss which weakens the structure of
the bones.
Many patients with primary hyperparathyroidism also have low vitamin D (25OHD) levels which
is thought to further impair bone health. Recent medical guidelines recommend treating
patients with primary hyperparathyroidism who have low vitamin D levels with oral vitamin D
but the optimal vitamin D dose and rate of repletion is unclear. It is, therefore, important
to determine if replenishing Vitamin D will improve bone health in primary
hyperparathyroidism, and if so, to assess the impact of the rate of vitamin D repletion.
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