Evaluation of the Effect of TMS on Primary Dysmenorrhea

Status Recruiting

Clinical Trial Summary

Based on the pain threshold and visual simulation score, primary dysmenorrhea patients will be divided into treatment effective group or non-effective group.According to the functional magnetic resonance imaging, the investigators investigate whether there is characteristic or secondary brain features before and after rTMS intervention.

Clinical Trial Description

Long term primary dysmenorrhea may induce a series of disorders involving psychology, lower quality of life, or even developing chronic organic lesion or chronic pain. Effective symptom improvement is urgently needed. During the Non-pharmaceutical interventions, repetitive transcranial magnetic stimulation (rTMS) is received preliminary approval because of its noninvasive and safe analgesic effect. In this randomized single blind longitudinal study, the investigators investigate the analgesic effect of rTMS in long term moderate-to-severe primary dysmenorrhea women. Based on the pain threshold and visual simulation score, primary dysmenorrhea patients will be divided into treatment effective group or non-effective group. According to the functional magnetic resonance imaging, the investigators investigate whether there is characteristic or secondary brain features before and after rTMS intervention. By combining pre and post performances of the degree of dysmenorrhea, behavioral data and sensitive hematological indicators, the investigators intend to build an association model between brain and pain development curve. Using correlation and multiple regression analysis method, the investigators intend to find sensitive neuroimaging biomarkers in predicting the analgesic effect of rTMS. The current study is not only contributing to improve the central nervous systematic mechanism of rTMS in chronic pelvic pain, but also significant for clinical effective treatment based on neuroimaging predictive markers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04168489
Study type	Interventional
Source	First Affiliated Hospital Xi'an Jiaotong University
Contact	wanghuan Dun, M.D.
Phone	0086-18092706568
Email	wanghuandun@163.com
Status	Recruiting
Phase	N/A
Start date	July 20, 2022
Completion date	July 30, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03608215` - Neuromodulatary Efficacy of Transcranial Direct Current Stimulation in Severe Refractory Primary Dysmenorrhea	N/A
Completed	`NCT03594916` - Efficacy of Transcranial Direct Current Stimulation for Severe Primary Dysmenorrhea	N/A
Not yet recruiting	`NCT04541134` - Phase 3 Clinical Trial to Evaluate of the Efficacy and Safety of DW9801 in Patients With Primary Dysmenorrhea	Phase 3
Completed	`NCT04083131` - Sense of Coherence and Primary Dysmenorrhea in High School Girls in Finistere, France
Not yet recruiting	`NCT05448027` - Low Versus High Intensity Laser Therapy on Primary Dysmenorrhea	N/A
Completed	`NCT04662814` - Extracorporeal Shock Wave Therapy for Dysmenorrhea	N/A
Recruiting	`NCT05771753` - Comparison of Core Stabilization and Dynamic Stretching Exercises in Primary Dysmenorrhea	N/A
Not yet recruiting	`NCT04665661` - Aerobic Exercise for Primary Dysmenorrhea	N/A
Completed	`NCT03290066` - Effectiveness of Kinesiotaping in Primary Dysmenorrhea	N/A
Completed	`NCT03593850` - Music for Pain in Primary Dysmenorrhea	N/A
Completed	`NCT04235595` - Comparison of the Effects of TENS and CTM on Primary Dysmenorrhea	N/A
Completed	`NCT05081869` - Investigation of the Effect of Online Yoga Based Exercise Program on Women With Primary Dysmenorrhea	N/A
Not yet recruiting	`NCT06398990` - The Effect of Cognitive Exercise Therapy Approach and Yoga in Adolescents With Dysmenorrhoea	N/A
Completed	`NCT02026206` - Low-level Light Therapy for Primary Dysmenorrhea	Phase 3
Completed	`NCT05686460` - Effect of Hegu Point Ice Massage and Music in Dysmenorrhea	N/A
Not yet recruiting	`NCT06052722` - The Relationship of Premenstrual Syndrome and Primary Dysmenorrhea With Severity of Temporomandibular Disorders	N/A
Completed	`NCT04119011` - Probiotics in Women With Primary Dysmenorrhoea	Phase 1/Phase 2
Active, not recruiting	`NCT05938660` - Effects of Acupressure at Sanyinjiao Point on Primary Dysmenorrhea Among University Students.	N/A
Completed	`NCT04856280` - Kinesiological Taping and Aerobic Exercise in Women With Primary Dysmenorrhea:	N/A
Completed	`NCT02602522` - Danshen-Jiang-Fu Granule Prepared by Danshen From Different Producing Areas for Primary Dysmenorrhea	Early Phase 1

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.