Clinical Trials Logo

Clinical Trial Summary

Background: Primary ciliary dyskinesia (PCD) is a rare genetic disease characterised by recurrent respiratory infections and subfertility due to dysfunction of cilia (brushes) of the lining cells. Undiagnosed and untreated it can result in an irreversible crippling chronic lung disease. The diagnosis of PCD is a difficult one and involves the complex assessment of ciliary structure and function. Thus, PCD is under diagnosed and appropriate preventative and symptomatic treatment may be denied in many patients. In addition, the gene responsible for PCD is at present unknown, thus preventing pre-natal diagnosis and genetic counseling.

Working hypothesis and aims: Recently, it has become apparent that the evaluation of nasally expired nitric oxide (NO) constitutes a simple and non-invasive diagnostic method, which discriminates between PCD patients, PCD carriers and healthy controls at high rate of specificity and sensitivity. Testing is simple and last approximately one minute. We have recently identified a unique isolated Druze population with high prevalence of PCD. The high frequency of disease places this closed community at a high risk of undiagnosed PCD.

The aim of this project is to use nasal NO measurement as a screening tool to identify possible undiagnosed cases of PCD and PCD carriers in this high risk Druze population.


Clinical Trial Description

n/a


Study Design

Time Perspective: Prospective


Related Conditions & MeSH terms


NCT number NCT00739817
Study type Observational
Source Ziv Hospital
Contact Israel Amirav, MD
Phone 97246828712
Email amirav@012.net.il
Status Not yet recruiting
Phase N/A
Start date July 2010

See also
  Status Clinical Trial Phase
Recruiting NCT05889013 - Utility of PCD Diagnostics to Improve Clinical Care
Recruiting NCT01246258 - Otolith Function in Patients With Primary Ciliary Dyskinesia N/A
Completed NCT04858191 - Utilizing Hyperpolarized 129Xe Magnetic Resonance Imaging in Children With Primary Ciliary Dyskinesia
Completed NCT05712798 - Physiological Responses to Exercise Tests in Primary Ciliary Dyskinesia Compared With Healthy Individuals
Completed NCT03370029 - Respiratory Muscle Strength, Exercise Capacity and Physical Activity Levels in Children Primary Ciliary Dyskinesia
Completed NCT00368446 - Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung Disease
Recruiting NCT05374720 - Analysis of the Molecular Composition of Tubal Cilia in Patients With or Without Ectopic Pregnancy N/A
Completed NCT05816876 - Muscle Function, Exercise Capacity and Physical Activity Level in Primary Ciliary Dyskinesia and Kartagener Syndrome
Recruiting NCT04717115 - Genotype/Phenotype Correlation With Focus on Lung Function in Primary Ciliary Dyskinesia (PCD)
Recruiting NCT03320382 - Multiple Breath Washout, a Clinimetric Dataset
Recruiting NCT03279965 - MRI in Cystic Fibrosis and Primary Ciliary Dyskinesia N/A
Recruiting NCT04602481 - COVID-19 in People With Primary Ciliary Dyskinesia
Not yet recruiting NCT02704455 - Registry Study on Primary Ciliary Dyskinesia in Chinese Children N/A
Completed NCT00323167 - Rare Genetic Disorders of the Breathing Airways
Recruiting NCT05932316 - Evaluating Bronchodilator Response in Patients With Bronchiectasis N/A
Completed NCT03832491 - Effect of Game Based Approach on Oxygenation, Functional Capacity and Quality of Life in Primary Ciliary Dyskinesia N/A
Recruiting NCT05951478 - DCP (RaDiCo Cohort) (RaDiCo-DCP)
Completed NCT06028607 - Feasibility of Consumption of Nutritional Supplementation in Primary Ciliary Dyskinesia N/A
Recruiting NCT05685186 - A Longitudinal, Observational Study of Primary Ciliary Dyskinesia in Adults
Recruiting NCT05161858 - Longitudinal Characterization of Respiratory Tract Exacerbations and Treatment Responses in Primary Ciliary Dyskinesia