Glioma Clinical Trial
Official title:
Assistance in Neurosurgery by Extemporaneous Analysis of Magnetic Resonance of the Metabolic Content in Excised Tissues (ExtempoRMN)
The main ambition of this project is to develop, and provide the medical community, an
innovative method to analyze extemporaneously, during a neurosurgery operation, excised
tissues. This method is based on the analysis of the metabolic profile of excised tissues by
the technique of High-Resolution Magic-Angle Spinning (HR-MAS) Nuclear Magnetic Resonance
(NMR) spectroscopy. Indeed HRMAS NMR method can provide in a sufficiently short time lapse
(currently about 30 minutes but within our project a time lapse of 15 min or even less is
ultimately intended), medical information that can complement those obtained by classic
histological examination.
Primary purpose:
The main objective of this study is to determine the sensitivity of HRMAS NMR spectroscopy
in detecting residual tumor infiltration at the brain resection cavity. The investigators
aim to determine the relevance of the metabolic analysis compared to histological analysis
during a neurosurgery operation. This involves analyzing excised tissue samples, obtained
from the operating rooms of Strasbourg University Hospitals, and Colmar Hospital Center,
with no return to neurosurgeon for surgery.
Secondary purposes:
The secondary objectives of the protocol are to investigate the metabolome of different
types of brain tumors, in order to find prognostic and diagnostic markers. It consists in
detecting metabolomic factors of bad prognosis, and potential marker of good prognosis such
as the IDH mutation.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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