Primary Angle Closure Clinical Trial
Official title:
A Randomised Comparative Study of the Effects of Cataract Extraction With Lens Implant Alone Versus Cataract Extraction With Lens Implant and Goniosynechialysis on Outflow Facility in Patients With Primary Angle Closure Glaucoma.
The aim of the study is to determine which is the best treatment for people with cataract
and primary angle closure (PAC).In PAC, apposition of the iris tissue to the drainage
channels (Trabecular Meshwork-TM) of the eye results in damage and formation of adherences
between these structures (Peripheral anterior synaechiae-PAS) causing a mechanical
obstruction of the aqueous outflow via the TM. It is thought that cataract surgery combined
with mechanical separation of the iris from the TM with the breakage of PAS(we call this
separation 'goniosynechialysis') would make the pressure even lower as it would cause the
drain to open to a greater extent than cataract surgery alone. This technique is not new,
and the results have been very encouraging. Comparing this technique to cataract surgery
alone however, has not been done and this is exactly what we would like to do in order to
help us decide what is the best treatment.
In summary, the investigators propose that cataract surgery with goniosynechialysis would
lower intraocular pressure to a greater extent than cataract surgery alone in patients with
significant PAS.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
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