Correlation Between Angle Closure Glaucoma Data and Lens Zonule Status

Primary Angle Closure Glaucoma Clinical Trial

Official title:

Correlation Between Angle Closure Glaucoma Data and Lens Zonule Status

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06184620
• Other study ID #: YXLL-KY-2023(047)
• Status: Completed
• Start date: December 1, 2020
• Est. completion date: March 30, 2023

Study information

• Verified date: December 2023
• Source: Qianfoshan Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The goal of this observational study is to discuss the correlation between primary angle-closure glaucoma and the state of the suspended ligament of the lens and the pathogenesis of PACG by measuring the biological data of primary angle-closure glaucoma and observing its anatomical changes.

Description:

Patients clinically diagnosed with Primary angle-closure glaucoma (PACG) and normal control patients from December 2020 to January 2022 were enrolled in this study.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 263
• Est. completion date: March 30, 2023
• Est. primary completion date: March 30, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 47 Years to 91 Years

Eligibility

Inclusion Criteria:

• The depth of the anterior chamber is normal, and the whole corner of the chamber is open;
• The cup-to-plate ratio is less than 0.5;
• No family history of glaucoma.

Exclusion Criteria:

• Previous history of trauma or internal eye surgery in both eyes or one eye;
• Used "pilocarpine", "atropine" and other drugs to change the size of the pupil and the shape of the chamber Angle within 1 week;
• Combined with other eye diseases affecting the Angle and suspension ligament, such as uveitis, ciliary cyst, high myopia, retinal diseases, etc.;
• Can not cooperate with UBM and Angle scopy;
• Refuse to participate in this researcher.

Related Conditions & MeSH terms

• Glaucoma
• Glaucoma, Angle-Closure
• Primary Angle Closure Glaucoma

Locations

Country	Name	City	State
China	guangfu Dang	Jinan	Shandong

Sponsors (1)

Lead Sponsor	Collaborator
Guangfu Dang

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Axial Length (AL), Lens Thickness (LT),Lens Vault (LV), Pupil Diameter (PD),	Axial Length (AL), Lens Thickness (LT),Lens Vault (LV), Pupil Diameter (PD),	before operation
Primary	Anterior Chamber Depth (ACD) in seat and rectum position, White To White (WTW), pupil vault (LV), pupil diameter (PD), The Lens Zonular Length (LZL) and Angle Opening Distance at 500µm (AOD500) in the upper, lower, nasal and temporal directions	Anterior Chamber Depth (ACD) in seat and rectum position, White To White (WTW), pupil vault (LV), pupil diameter (PD), The Lens Zonular Length (LZL) and Angle Opening Distance at 500µm (AOD500) in the upper, lower, nasal and temporal directions	before operation