Optical Coherence Tomography Quantitative Analysis of Changes in Anterior Chamber After Laser Peripheral Lridotomy

Primary Angle Closure Glaucoma Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02279472
• Other study ID #: SecondXHCSU
• Status: Recruiting
• Phase: N/A
• First received: September 30, 2014
• Last updated: October 28, 2014
• Start date: October 2014
• Est. completion date: January 2015

Study information

• Verified date: October 2014
• Source: Second Xiangya Hospital of Central South University
• Contact: Haomin Luo, Ph.D student
• Phone: +86 13875830738
• Email: lhmqqpp[@]163.com
• Is FDA regulated: No
• Health authority: China: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to analysis changes in anterior segment morphology after laser peripheral lrldotomy measured by optical coherence tomography, and to evaluate treatment effectiveness

Description:

In the study ,primary angle closure(PAC) and primary angle closure glaucoma (PACG) will be recruited. Anterior segment optical coherence tomography images captured before and after laser peripheral iridotomy will be analysed to provide objective and reproducible quantification of anterior segment biometric parameters.The outcomes can provide useful information for clinical strategies in the treatment and management of pathology related to angle closure.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 40
• Est. completion date: January 2015
• Est. primary completion date: December 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 30 Years to 80 Years

Eligibility

Inclusion Criteria:

1 .The gonioscopy or UBM examination has confirmed the diagnosis of PACS or PAC 2. Intraocular pressure within 10 to 21 mmHg ,C/D=0.6 3. Visual field is normal or only show paracentral scotoma 4. Vision or corrected visual acuity =0.8 5. Refractive degree no more than 200D 6. Exclude other ocular and systemic diseases

Exclusion Criteria:

1. Corneal macula and other corneal diseases, ocular surface disease or corneal edema

2. Iridocyclitis

3. Ocular trauma and intraocular operation history

4. No fixationFundus lesions such as diabetic retinopathy or retinal detachment

5. No fixation

6. Ocular or systemic application of cortical steroids -

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Glaucoma, Angle-Closure
• Primary Angle Closure Glaucoma

Intervention

Procedure:
• Laserex Tango Nd:YAG, Ellex-SuperQ Medical, Australia
All the patients will be achieved with pilocarpine 1% for pupil constriction, laser peripheral iridotomy(LPI) is performed using the ophthalmic neodymium: yttrium aluminium garnet laser (Laserex Tango Nd:YAG, Ellex-SuperQ Medical, Australia) and an VOLK iridotomy contact lens. After LPI, patients will be given topical prednisolone acetate 0.1% for 7 days.

Locations

Country	Name	City	State
China	The Second Xiangya Hospital of Central South University,	Changsha	Hunan

Sponsors (1)

Lead Sponsor	Collaborator
Second Xiangya Hospital of Central South University

Country where clinical trial is conducted

China, 

References & Publications (2)

Lee KS, Sung KR, Shon K, Sun JH, Lee JR. Longitudinal changes in anterior segment parameters after laser peripheral iridotomy assessed by anterior segment optical coherence tomography. Invest Ophthalmol Vis Sci. 2013 May 3;54(5):3166-70. doi: 10.1167/iovs.13-11630. — View Citation

Memarzadeh F, Li Y, Chopra V, Varma R, Francis BA, Huang D. Anterior segment optical coherence tomography for imaging the anterior chamber after laser peripheral iridotomy. Am J Ophthalmol. 2007 May;143(5):877-9. Epub 2006 Dec 29. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in anterior chamber after LPI at 1 month		1month	No