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CXCR4 Targeted PET Imaging in the Diagnosis and Identification of Primary Aldosteronism

Primary Aldosteronism Clinical Trial

Official title:
CXCR4 Targeted PET Imaging in the Diagnosis and Identification of Primary Aldosteronism

Clinical Trial Summary

This study aimed to prospectively evaluate the utility of C-X-C chemokine receptor type 4 (CXCR4) positron emission tomography (PET) imaging in patients with clinical suspected primary aldosteronism (PA), with postoperative pathological or follow-up results as reference standards.

Clinical Trial Description

1. Record the course of disease, the laboratory examination (e.g., potassium, aldosterone, aldosterone-to-renin ratio, intravenous salt-loading test or captopril test) and the results of adrenal vein sampling in patients with clinically suspected PA. 2. PET image analysis: Record and evaluate the following indicators: the maximum standardized uptake value (SUVmax) of lesions, the mean standardized uptake value (SUVmean) of normal liver, the SUVmean of adjacent normal adrenal tissue, the ratio of the lesional SUVmax to the normal liver SUVmean (LLR), and the ratio of the lesional SUVmax to the adjacent adrenal tissue SUVmean (LAR). 3. Pathological analysis: Hematoxylin and eosin staining and immunohistochemical analyses will be performed. Immunohistochemical analysis will be used to investigate the expression of aldosterone synthase (CYP11B2) and CXCR4. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06183554
Study type Observational
Source Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Contact Xiao Chen, Ph.D
Phone +8615922970174
Email xiaochen229@foxmail.com
Status Recruiting
Phase
Start date August 31, 2023
Completion date August 31, 2025
View Details
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