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Primary Aldosteronism LC-MS/MS-specific Cutoffs — PM  

Primary Aldosteronism Clinical Trial

Official title:
LC-MS/MS-specific Cutoffs for Screening and Confirmatory Testing of Primary Aldosteronism: A Multi-center Study

Clinical Trial Summary

Aims to evaluation the LC-MS/MS-specific cutoffs of PA screening and CCT test.

Clinical Trial Description

Plasma aldosterone concentration and plasma renin activity / concentration measurement are important for early screening and diagnosis of Primary Aldosteronism (PA), most measurement methods are currently based on chemiluminescence, which may be cross-reactivity with other compounds and metabolites, leading to misdiagnosis or missed diagnosis of PA patients. Liquid chromatography tandem mass spectrometry (LC-MS/MS) has been introduced into the clinical routine analysis of steroid hormones due to its higher specificity and is increasingly used for the diagnosis of adrenal diseases. However, it is unknown for the cut-offs of PA screening and CCT test based on this technology in China. Therefore, the purpose of this study is to establish the screening and CCT cut-off point for primary aldosteronism based on LC-MS/MS technique at multicenter in China. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05959863
Study type Observational
Source Chongqing Medical University
Contact Qifu Li, PhD
Phone 18696676815
Email liqifu@yeah.net
Status Recruiting
Phase
Start date August 30, 2023
Completion date June 30, 2024
View Details
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