Nuclear Imaging for Subtype Diagnosis of Primary Aldosteronism

Status Not yet recruiting

Clinical Trial Summary

This study is to evaluate the accuracy of a novel radiopharmaceutical tracer, para-chloro-2-[18F]fluoroethyl etomidate (CETO), used with positron emission tomography (PET) and computed tomography (CT), as a way to subtype unilateral vs. bilateral forms of Primary Aldosteronism, compared to AVS as a reference gold standard.

Clinical Trial Description

This is a phase II study (with targeted recruitment of 30 participants) designed to evaluate the accuracy of a novel radiopharmaceutical tracer, para-chloro-2-[18F]fluoroethyl etomidate (CETO), used with positron emission tomography (PET) and computed tomography (CT), as a way to subtype unilateral vs. bilateral forms of Primary Aldosteronism, compared to AVS as a reference gold standard. Subjects consenting to study participation will receive the [18-F] CETO followed by the PET/CT scan. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05472493
Study type	Interventional
Source	University of Calgary
Contact	Alexander Leung, MD
Phone	(403) 955-8358
Email	aacleung@ucalgary.ca
Status	Not yet recruiting
Phase	Phase 2
Start date	January 1, 2023
Completion date	June 30, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02885662` - Study of CS-3150 in Patients With Primary Aldosteronism	N/A
Withdrawn	`NCT02096939` - Microvascular Function in Primary Aldosteronism	N/A
Completed	`NCT01728493` - Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment	N/A
Recruiting	`NCT06228677` - Comparison of Catecholamine Concentrations in Venous Blood During Selective Adrenal Artery Embolization
Recruiting	`NCT06047912` - Screening for Primary Aldosteronism in Hypertension With 24-hour URinary aLdosterone
Recruiting	`NCT04991961` - Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Screening for Primary Aldosteronism
Recruiting	`NCT05405101` - Randomised Trial Comparing Thermal Ablation With Adrenalectomy in the Treatment of Unilateral Asymmetric PA	N/A
Recruiting	`NCT05501080` - The Effect of SAAE on Ventricular Remodeling in PA Patients	N/A
Recruiting	`NCT05826080` - Effect of Adrenocorticotropic Hormone Stimulation During Adrenal Vein Sampling in Primary Aldosteronism
Recruiting	`NCT05973604` - Prevalence of Primary Aldosteronism in Atrial Fibrillation
Completed	`NCT04179019` - Calcium Channel Blockade in Primary Aldosteronism	Phase 2
Completed	`NCT03500120` - Diagnostic Accuracy of Seated Saline Suppression Test for Primary Aldosteronism
Recruiting	`NCT04213963` - Prospective Study on Primary Aldosteronism in Resistant Hypertension
Completed	`NCT05435703` - Renal Cysts and Primary Aldosteronism
Recruiting	`NCT02945904` - IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients With Primary Hyperaldosteronism
Enrolling by invitation	`NCT02257450` - Primary Aldosteronism in Malaysia: A Nationwide Multicentre Study	N/A
Recruiting	`NCT05561361` - The Effect of SAAE on Vascular Endothelial Function in PA Patients
Completed	`NCT03398785` - Adrenal Artery Ablation Treats Primary Aldosteronism	Phase 3
Recruiting	`NCT04428827` - Outcome of Patients With Primary Aldosteronism
Recruiting	`NCT03224312` - Chongqing Primary Aldosteronism Study