Prevention of Obesity Clinical Trial
Official title:
The Effect of Protein and Calcium on Weight Change and Blood Lipid Profile
The primary aim is to examine the effect of a high protein intake (from soy or whey protein)
on weightmaintenance after weight loss in a group of predisposed (severe) obese persons.
Furthermore, to examine short-term and long-term effect of a high protein intake on appetite
regulation and diet induced thermogenese (DIT). Finally to examine the effect of calcium on
weightmaintence, bloodlipid profilen, appetite regulation and DIT.
The study is a parallel RCT with a weight loss (WL) period (8 weeks on very low calorie
diet) and a weightmaintence (WM) period (24 weeks daily intake of supplement). 200
overweight/obese subjects will be enrolled into the study and randomized to placebo
(maltodextrin), soy protein, whey protein or calcium enriched whey protein supplement. At
baseline (week 0), after the WL period (week 8) and after WM period (week 24) body weight
and composition will be measured and blood samples will be collected. Meal test will be
performed at week 0 and 24 (examining both appetite regulation and DIT). Urine and feces
will be collected three times during the study. Subjects will receive dietary counseling (in
groups) regularly during the study and body weight will be measured at each visit.
n/a