Preterm Clinical Trial
Official title:
Preterm Immune System Development and Response to Immunization
In this study the response to vaccination and development of the immune system in very preterm infants upon the current vaccination schedule will be compared to healthy term infants.
Preterm infants are at increased risk of developing infections early in life due to a less mature immune system compared to full-term infants. Moreover, protection by the placental transfer of maternal antibodies in general and specifically against vaccine antigens has shown to be significantly lower in very preterm infants (gestational age (GA)< 32 weeks) compared to term infants. In this study we aim to investigate the immune system development of very preterm infants. Adequate immune response to vaccination is considered both clinically important as well as a functional test of the immune system. However, data on the antibody and Ag-specific memory B cell response to vaccination in preterm infants are limited. Primary objective is to study the antibody immune response to routine vaccinations in very preterm infants (GA<32 weeks). Secondary aim is to study the immune system more extensively using flow cytometry, ELISA and single cell transcriptomics to measure development of Ag-specific memory B cells raised in response to vaccination, and by using proteomics, epigenetics, and microbiome studies. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT06105333 -
Fidgety Movements of Preterm Neonates Included in COSGOD III
|
||
Recruiting |
NCT05729321 -
Lock sOlutiOnS for Epicutaneo-caval Catheters in Neonates: a "LOOSEN" Pilot Study
|
||
Completed |
NCT05509621 -
The Effect of Positions on Physiological Parameters of Preterm Neonates Receiving Mechanical Ventilation
|
N/A | |
Enrolling by invitation |
NCT06116747 -
The SUPPORTED Study - First-time Fathers of Preterm Infants.
|
N/A | |
Active, not recruiting |
NCT01443195 -
Iron Metabolism in Small Pre Term Newborns
|
N/A | |
Withdrawn |
NCT05053269 -
Body Weight Growth After Birth and Bronchopulmonary Dysplasia
|
||
Not yet recruiting |
NCT06118801 -
The Effect of Probiotics Added to the Mother's Diet on Preterm Babies
|
N/A | |
Completed |
NCT05453734 -
The Effect of Progressive Muscle Relaxation Exercises
|
N/A | |
Recruiting |
NCT05230199 -
Sensory Optimization of the Hospital Environment
|
N/A | |
Completed |
NCT06204146 -
The Effect of Massage on Growth And Stress And Stress ,Department of Nursing,
|
N/A | |
Recruiting |
NCT05687500 -
Oral Glibenclamide in Preterm Infants With Hyperglycaemia (GALOP)
|
Phase 2 | |
Completed |
NCT05830955 -
The Effect of Lullaby and Breastmilk Smell on Preterm Newborns
|
N/A | |
Active, not recruiting |
NCT06246032 -
Impact of Modified Feeding Protocol on Neonatal Outcomes
|
N/A | |
Completed |
NCT05359809 -
Peripheral Intravenous Central Catheter Intervention in Preterm Infants
|
N/A | |
Not yet recruiting |
NCT05331235 -
Blood Transfusions in Preterm Infants
|
||
Not yet recruiting |
NCT05434364 -
Comparison Three Methods on Endotracheal Aspiration in Preterm Infants
|
N/A | |
Completed |
NCT05805254 -
Neurofunctional Study of Preterm Infants' Brain Activity
|
||
Completed |
NCT01776281 -
Effects of Kangaroo Mother Care Among Low Birth Weight (LBW) and Preterm Infants
|
Phase 2 | |
Completed |
NCT05978674 -
The Effect of Rocking Bed on Preterm Newborns
|
N/A | |
Completed |
NCT05261503 -
Investigation of the Effectiveness of Environmental Enrichment-Based Intervention in Preterm Infants
|
N/A |