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High Flow Nasal Cannula Versus Nasal Intermittent Positive Pressure (NIPPV) in Preterm Infants — VAPORAM  

Preterm Infant Clinical Trial

Official title:
A Multicenter Randomized Controlled Trial Comparing High Flow Nasal Cannula and NIPPV in Preterm Infants

Clinical Trial Summary

The aim of this study is to compare the effectiveness of Heated Humidified High Flow Nasal Cannula (HHHFNC) versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) in preventing intubation when used as primary respiratory support for Respiratory Distress Syndrome (RDS) or post extubation in preterm infants

Clinical Trial Description

Patient population will include preterm infants born at 24 - 36+6 weeks of gestation who are candidates for non-invasive respiratory support post extubation or as primary respiratory support after birth. They will be will be randomized to 2 groups: Heated Humidified High Flow Nasal Cannula (HHHFNC) and Nasal Intermittent Positive Pressure Ventilation (NIPPV). This will be a prospective unblinded randomized controlled study, designed as a non-inferiority trial. Primary outcome: The primary outcome will be rate of treatment failure (need for intubation) within 7 days of starting the study treatment ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03853161
Study type Interventional
Source Carmel Medical Center
Contact Ayala Gover, MD
Phone 972-528-396948
Email ayalagover@gmail.com
Status Recruiting
Phase N/A
Start date January 21, 2018
Completion date July 1, 2023
View Details
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