Hearing and Cognition in Aging Adults

Presbycusis Clinical Trial

— ACAV  

Official title:

Hearing and Cognition in Aging Adults

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06183450
• Other study ID #: RC31/22/0252
• Secondary ID: 2023-A01415-40
• Status: Not yet recruiting
• Start date: January 2024
• Est. completion date: January 2033

Study information

• Verified date: December 2023
• Source: University Hospital, Toulouse
• Contact: Mathieu Marx, Pr
• Phone: 05 61 77 77 04
• Email: marx.m[@]chu-toulouse.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This cohort study is expected to provide valuable insights into the complex interplay between auditory and cognitive functions and how they change over time. The results of this study will have important implications for the prevention, diagnosis, and treatment of age-related hearing and cognitive disorders

Description:

The aim of the study is to identify the early perceptual and cognitive alterations related to age-related hearing loss or presbycusis, establish a correlation between the degree of hearing loss and the deterioration of cognitive functions, and examine the effectiveness of hearing loss management in reversing observed cognitive impairments. This project has the potential to shed light on the importance of early detection of hearing impairments in preventing cognitive decline. The data collected from this cohort, rigorously assessed for both auditory and cognitive functions, could serve as the basis for several high-level scientific investigations.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 262
• Est. completion date: January 2033
• Est. primary completion date: January 2033
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 45 Years to 50 Years

Eligibility

Inclusion Criteria:

• Normal hearing (Pure Tone Audiometry < or = 20 dB)
• Residency in one of the three neighborhoods :
• Affiliation with a social security system

Exclusion Criteria:

• Individuals under guardianship, trusteeship or curators
• History of neurological pathologies
• Taking of psychotropic medication.

Related Conditions & MeSH terms

• Presbycusis

Intervention

Diagnostic Test:
• auditory level
Evaluation of auditory thresholds through audiometric tests. Evaluation of speech comprehension in noise through a vocal audiometry test in noise (FraMatrix). Evaluation of spatial auditory behavior and spatial precision using a spatial discrimination test (Minimum Audible Angle) and a static sound localization test in virtual reality.
• cognitive level
Evaluation of attention and short-term memory functions with verbal and non-verbal tasks: Digit Span Test and Reading Span Test. Evaluation of inhibition capacities using the Stroop Test. Evaluation of executive functions, visual attention, reasoning, and mental arithmetic using the Raven's Matrix test.
• quality of life level
- Evaluation of quality of live level via Speech, Spatial and Qualities of Hearing Scale (SSQ-12) and EuroQol-5D questionnaires.

Locations

Country	Name	City	State
France	Ecole d'audioprothèse	Cahors

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Toulouse

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Pure-ton audiometry	Pure-tone audiometry will be evaluated by collecting the threshold in air and bone conduction for both ears on each frequency tested (125-250-500-1000-2000-4000 and 8000 Hz), as well as the average hearing loss (MAP ) on all five frequencies.	5 years